14 April 2017 : Case report
Unusual or unexpected effect of treatment, Rare disease, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)Kazuhiro Takahashi1ABCDEF*, Pauline Go1ABCDEF, Chad H. Stone2D, Mohamed Safwan1E, Krishna G. Putchakayala1BC, William J. Kane1E, Lauren E. Malinzak1E, Dean Y. Kim1E, Jason E. Denny1ACDEFG
Am J Case Rep 2017; 18:399-404
BACKGROUND: Mycophenolate mofetil (MMF) induced lung disease has been described in only a few isolated reports. We report a case of fatal respiratory failure associated with MMF after kidney transplantation.
CASE REPORT: A 50-year-old Hispanic male with a history of end-stage renal disease secondary to hypertension underwent deceased donor kidney transplantation. His preoperative evaluations were normal except for a chest x-ray which showed bilateral interstitial opacities. Tacrolimus and MMF were started on the day of surgery. His postoperative course was uneventful and he was discharged on postoperative day 5. One month later, he presented with shortness of breath and a cough with blood-tinged sputum. His respiratory condition deteriorated rapidly, requiring intubation. Chest computer tomography (CT) demonstrated patchy ground-glass opacities with interlobular septal thickening. Comprehensive pulmonary, cardiac, infectious, and immunological evaluations were all negative. Open lung biopsy revealed extensive pulmonary fibrosis with no evidence of infection. He temporarily improved after discontinuation of tacrolimus and MMF, however, on resuming MMF his respiratory status deteriorated again and he subsequently died from hypoxic respiratory failure.
CONCLUSIONS: An awareness of pulmonary lung disease due to MMF is important to prevent adverse outcomes after organ transplantation. MMF must be used with utmost care in recipients with underlying lung disease as their pulmonary condition might make them more susceptible to any harmful effects of MMF.
Keywords: Abnormalities, Drug-Induced, Immunosuppressive Agents, Pulmonary Fibrosis, Tacrolimus
01 Feb 2024 : Case reportConservative versus Surgical Treatment of Pneumatosis Intestinalis: Experience from a Multidisciplinary Center
Am J Case Rep In Press; DOI: 10.12659/AJCR.943166
08 Feb 2024 : Case reportRight Thigh Mass Metastasis from Lung Cancer Mimicking Primary Soft Tissue Sarcoma: A Case Report
Am J Case Rep In Press; DOI: 10.12659/AJCR.942416
05 Feb 2024 : Case reportUnraveling the Uncommon: A Case Report of Giant Cell Myocarditis and Examination of Existing Literature
Am J Case Rep In Press; DOI: 10.12659/AJCR.942381
Most Viewed Current Articles
10 Jan 2022 : Case reportA Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...
Am J Case Rep 2022; 23:e935263
19 Jul 2022 : Case reportAtlantoaxial Subluxation Secondary to SARS-CoV-2 Infection: A Rare Orthopedic Complication from COVID-19
Am J Case Rep 2022; 23:e936128
05 Mar 2022 : Case reportAcute Limb Ischemia After Self-Injection of Crushed Morphine Tablets into the Radial Artery: Role of Infrar...
Am J Case Rep 2022; 23:e935336