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15 August 2017 : Case report  France

Off-Label Use of Crizotinib as a Neoadjuvant Treatment for a Young Patient When Conventional Chemotherapy Gave No Benefits in Stage IIIA Non-Small Cell Lung Cancer

Unusual setting of medical care, Unexpected drug reaction , Educational Purpose (only if useful for a systematic review or synthesis)

Delphine Dumont1BCDEF*, Pascal Dô2B, Delphine Lerouge1DE, Gaëtane Planchard3D, Marc Riffet3BE, Catherine Dubos-Arvis2D, Serge Danhier1E, Radj Gervais2BCDEF

DOI: 10.12659/AJCR.903528

Am J Case Rep 2017; 18:890-893

Abstract

BACKGROUND: The treatment of locally advanced non-small cell lung cancer involves a combination of chemotherapy, surgery, and radiotherapy. Each case is discussed and the best strategy is chosen individually, following international guidelines.

CASE REPORT: A 37-year-old man was diagnosed with locally advanced broncho-pulmonary adenocarcinoma (stage IIIA). The disease was stable after 2 cycles of cisplatin plus Navelbine used as neoadjuvant therapy. FISH analysis revealed an ALK rearrangement. The patient then received unlicensed crizotinib as second-line neoadjuvant treatment, which led to an almost complete radiological and metabolic response. A left upper lobectomy was performed, followed by post-operative chemotherapy and radiotherapy. At 18 months post-surgery, the patient is still disease-free according to the last CT scan.

CONCLUSIONS: Targeted therapy was an alternative solution when chemotherapy was not helping. Randomized studies are needed to define its precise role in the neoadjuvant scheme.

Keywords: Molecular Targeted Therapy, Neoadjuvant Therapy

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Am J Case Rep In Press; DOI: 10.12659/AJCR.938335  

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923