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01 September 2017 : Case report  Denmark

Recurrent Cardiovascular Events Despite Antiplatelet Therapy in a Patient with Polycythemia Vera and Accelerated Platelet Turnover

Unusual clinical course, Unusual or unexpected effect of treatment

Oliver Heidmann Pedersen12CDEF*, Mads Lamm Larsen13CDEF, Steen Dalby Kristensen14DEF, Anne-Mette Hvas24DEF, Erik Lerkevang Grove14ADEF

DOI: 10.12659/AJCR.904148

Am J Case Rep 2017; 18:945-948

Abstract

BACKGROUND: Clopidogrel is commonly used in the prevention and treatment of cardiovascular events. However, despite clopidogrel treatment, some patients experience recurrent ischemic events.

CASE REPORT: We present the case of a 58-year-old man with polycythemia vera and concomitant thrombocytosis who suffered 6 episodes of cerebral infarctions and 1 myocardial infarction, despite treatment with clopidogrel. Following his last ischemic event, the antiplatelet therapy was intensified from initially clopidogrel monotherapy to dual antiplatelet therapy with aspirin 75 mg once daily and ticagrelor 90 mg twice daily. Since then, no cardiovascular event has been reported.

CONCLUSIONS: This case report illustrates that insufficient platelet inhibition with clopidogrel monotherapy in a patient with thrombocytosis may be associated with recurrent arterial thrombosis. The exact reasons for the insufficient platelet inhibition are not known, but a plausible explanation may be an accelerated platelet turnover reflected by an increased number of immature platelets in this patient.

Keywords: Blood Platelets, Platelet Aggregation, Platelet Aggregation Inhibitors, Platelet Count, Purinergic P2Y Receptor Antagonists, Thrombocytosis

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923