BACKGROUND: Radiation-associated breast angiosarcoma is a rare clinical entity that is thought to be increasing in incidence.

CASE REPORT: Here we present the case of a 67-year-old female with a history of left breast invasive ductal carcinoma who received breast conserving surgery and radiation therapy eight years ago. She then presented with a painless mild skin discoloration of the left breast that had been present for over one year. Mammograms and ultrasounds were normal. A punch biopsy and a subsequent excisional biopsy revealed the diagnosis of angiosarcoma. The patient was treated with mastectomy and had no subsequent recurrences.

CONCLUSIONS: The long-term clinical surveillance for all patients who receive breast conservation surgery is recommended and a high degree of suspicion should be exercised in view of potential atypical presentations of this disease.

Keywords: Heavy Ion Radiotherapy, Hemangiosarcoma, Mastectomy