BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) accounts for the large majority of AIDS-related non-Hodgkin’s lymphoma (NHL). DLBCL usually arises in lymph nodes, presenting as a painless rapid swelling mass in the neck, armpit, or groin.

CASE REPORT: Here, we report a case of DLBCL that needed only 3 months to develop a tumor 20×15 cm in diameter in the right groin and even caused scrotum swelling and lower-extremity edema. Furthermore, this case of DLBCL had developed other 3 subcutaneous tumors in the chest wall and their diameters were 16×9 cm, 7×7 cm, and 3×3 cm. A thoracic computed tomography (CT) scan presented with bilateral pleural effusion and the chest wall tumors with rib lesions.

CONCLUSIONS: It is rare that a DLBCL needed only 3 months to develop a tumor 20×15 cm in diameter and even caused scrotum swelling and unilateral lower-extremity edema due to the large mass located in the right groin. Furthermore, it is extremely rare that this lymphoma infiltrated the chest wall and even resulted in rib lesions.

Keywords: case reports, HIV Infections, Lymphoma, B-Cell