Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

23 February 2018 : Case report  China (mainland)

Breast Metaplastic Squamous Cell Carcinoma Diagnosed with Fine Needle and Core Biopsy: A Case Study

Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease

Na Cha1AEF, Shiyu Wang2EF, Ming Lv3DF, Dong-Wei Wang1AB, Xiao-Jie Zhang4B, Min Zheng4A, Li-Xiang Tian1DE*

DOI: 10.12659/AJCR.907254

Am J Case Rep 2018; 19:203-206

Abstract

BACKGROUND: Breast metaplastic squamous cell carcinoma (SCC) is a rare primary breast carcinoma, and overexpression of HER2 in this carcinoma is extremely uncommon.

CASE REPORT: We presented a case of a 48-year-old Asian female with breast metaplastic SCC. Fine needle aspiration biopsy (FNAB) and core needle biopsy (CNB) of the lesion were taken prior to surgical resection. FNAB smears demonstrated highly atypical squamous cells and a diagnosis positive for malignancy was rendered. CNB and a surgical resection specimen revealed invasive squamous carcinoma with keratin pearl formation and intercellular bridges. Further study demonstrated this was an unusual metaplastic SCC case with basal-HER2 (+) phenotype. HER2 has been linked to poor prognosis and response to therapy.

CONCLUSIONS: The pathological diagnosis of the breast metaplastic SCC was made initially by FNAB and CNB. Identification of basal-HER2 (+) phenotype was critical for selection of hormonal therapies and chemotherapy.

Keywords: Genes, erbB-2, Mass Behavior, Metaplasia, Neoplasms, Squamous Cell

Add Comment 0 Comments

In Press

Case report  Belgium

Takotsubo Syndrome-Induced Cardiogenic Shock in Lung Transplantation: Importance of Early Diagnosis and ECM...

Am J Case Rep In Press; DOI: 10.12659/AJCR.944942  

Case report  China

Priapism Following Coronary Angiography: A Case Report and Clinical Insights for Diagnosis and Management

Am J Case Rep In Press; DOI: 10.12659/AJCR.943609  

Case report  USA

Anterior Mitral Line Ablation-Induced Complete Heart Block: A Cautionary Case Study

Am J Case Rep In Press; DOI: 10.12659/AJCR.945818  

Case report  South Korea

Dual-Plate Fixation in Treatment of Clavicle Fractures in Dementia Patients: A Case Series

Am J Case Rep In Press; DOI: 10.12659/AJCR.945489  

Most Viewed Current Articles

21 Jun 2024 : Case report  China (mainland) 72,630

Intracranial Parasitic Fetus in a Living Infant: A Case Study with Surgical Intervention and Prognosis Anal...

DOI :10.12659/AJCR.944371

Am J Case Rep 2024; 25:e944371

0:00

07 Mar 2024 : Case report  USA 44,111

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

10 Jan 2022 : Case report  Germany 32,596

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

23 Feb 2022 : Case report  USA 20,506

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923