27 April 2018
: Case report
Endometrial Metastasis from Ductal Breast Carcinoma: A Case Report with Literature Review
Unusual clinical course, Challenging differential diagnosis
Maryam Rahmani1ABCDG, Fatemeh Nili2ABCD, Elnaz Tabibian1BCEF*DOI: 10.12659/AJCR.907638
Am J Case Rep 2018; 19:494-499
Abstract
BACKGROUND: There are few reports of breast cancer cases with uterine metastases; among them, myometrium is more frequently involved than endometrium. The majority of breast cancer metastases to endometrium are lobular type, and there have been only 5 reported cases of ductal type since 1984. Here, we describe a new case of invasive ductal carcinoma with metastases to endometrium and isolated presentation of abnormal uterine bleeding, in addition to reviewing the existing literature on other similar cases.
CASE REPORT: The patient was a 51-year-old Persian woman with no remarkable past medical or family history of cancer, who presented with a 6-month complaint of menorrhagia to our gynecology clinic. Diagnostic studies including trans-vaginal ultrasonography, pathological examination of endometrial curettage specimen, immunohistochemistry findings, and X-plane and magnetic resonance mammography, and breast core-needle biopsy revealed invasive ductal breast carcinoma as the origin of the endometrial metastasis.
CONCLUSIONS: Abnormal uterine bleeding in a premenopausal patient should alert clinicians to the possibility of secondary as well as primary neoplasms. It is necessary to differentiate a metastatic tumor from a primary one, since the treatment and prognosis are completely different.
Keywords: Carcinoma, Ductal, Breast, case reports, Endometrium, Menorrhagia
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