07 April 2018
: Case report 
Tachyphylaxis to the Sedative Action of Mirtazapine
Unusual clinical course, Unusual or unexpected effect of treatment, Patient complains / malpractice, Adverse events of drug therapy
Georgios Papazisis1ABDE*, Spyridon Siafis1BDF, Dimitrios Tzachanis12EGDOI: 10.12659/AJCR.908412
Am J Case Rep 2018; 19:410-412
Abstract
BACKGROUND: The pharmacological term tachyphylaxis is used to describe rapidly occurring response desensitization, a situation where the biological response to a given drug dose diminishes when it is given continuously. This pharmacological phenomenon is well observed in some drug categories such as ephedrine, nitrates, beta blockers and H2 antagonists. Mirtazapine is a widely-used antidepressant with a multimodal mechanism of action.
CASE REPORT: In the present case, we report rapid onset and consistent tachyphylaxis regarding the sedative action of mirtazapine in a 30-year-old female.
CONCLUSIONS: To our knowledge this is the first reported case of rapid onset and consistent tachyphylaxis to the sedative effect of mirtazapine confirming the complexity of the pharmacological profile of the drug.
Keywords: Conscious Sedation, Histamine Antagonists, Tachyphylaxis
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