10 April 2018
: Case report
Corneal Opacity Leading to Multiple Myeloma Diagnosis: A Case Report and Literature Review
Challenging differential diagnosis, Rare disease
Naiyang Li12ABCEG*, Zhe Zhu3BCE, Gengrong Yi1BCF, Sheng Li1BDE, Xiaotong Han1BCDOI: 10.12659/AJCR.908475
Am J Case Rep 2018; 19:421-425
Abstract
BACKGROUND: A multiple myeloma patient presenting with corneal opacity and blurred vision as chief complaint is rare.
CASE REPORT: A 54-year-old woman with a 9-month history of blurred vision without other systemic symptoms consulted an ophthalmologist. The patient had bilateral diffuse corneal opacity at the corneal epithelium and anterior stroma under slit-lamp examination. Decreased corneal endothelial cells density was found by microscopy. During consultation, the patient was noted to have an anemic face. Laboratory analysis and bone marrow were investigated. Serum protein electrophoresis revealed a raised serum kappa paraprotein band (12.4 g/L). The erythrocyte sedimentation rate (ESR) was accelerated to 49 mm/h (normal <20mm/h). There was mild kidney impairment. The blood urea increased to 8.1 mmol/L (normal <7.1 mmol/L) and creatinine increased to 158 μmol/L (normal <133 μmol/L). Then, a bone marrow biopsy was performed, showing 26% pleomorphic plasma cells (normal <15%). The patient was eventually diagnosed as having MM and was treated with systemic chemotherapy.
CONCLUSIONS: Blurred vision due to corneal opacity can be an initial presentation of MM, of which ophthalmologists should be aware.
Keywords: Antibodies, Monoclonal, Corneal Opacity, Multiple Myeloma
SARS-CoV-2/COVID-19
21 March 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938730
21 March 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938659
22 February 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938732
22 February 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938761
In Press
23 Mar 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.939489
22 Mar 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.938774
22 Mar 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.939650
22 Mar 2023 : Case report
Am J Case Rep In Press; DOI: 10.12659/AJCR.939530
Most Viewed Current Articles
13 Jul 2022 : Case report
DOI :10.12659/AJCR.936441
Am J Case Rep 2022; 23:e936441
06 Dec 2021 : Case report
DOI :10.12659/AJCR.934406
Am J Case Rep 2021; 22:e934406
23 Feb 2022 : Case report
DOI :10.12659/AJCR.935250
Am J Case Rep 2022; 23:e935250
07 Dec 2021 : Case report
DOI :10.12659/AJCR.934347
Am J Case Rep 2021; 22:e934347