11 June 2018 : Case report
Rhabdomyolysis Following Initiation of Antiviral Therapy with Oseltamivir
Adverse events of drug therapy
Harika Puttagunta1BEF, Saleh Alghsoon2BEF, Prudhvi Regula3BE, Shruthimurthy Hassankrishnamurthy4BE, Vamsi K. Kota56ADE*DOI: 10.12659/AJCR.909278
Am J Case Rep 2018; 19:673-677
Abstract
BACKGROUND: Tamiflu (oseltamivir phosphate) serves as prophylaxis and treatment of upper respiratory tract infections (URTI) and lower respiratory tract infections (LRTI) caused by viruses of the Orthomyxovirus family. Here, we present a patient with URTI and negative rapid influenza diagnostic testing (RIDT), who developed rhabdomyolysis after being started on oseltamivir.
CASE REPORT: Our report describes a rare case of rhabdomyolysis after oseltamivir administration in a 53-year-old man with suspected influenza. We discuss the differential diagnosis for rhabdomyolysis to rule out other causes and review the literature on influenza-induced rhabdomyolysis.
CONCLUSIONS: Considering the serious consequences of rhabdomyolysis, care needs to be taken in routine prescription and use of oseltamivir. Although this is a rare adverse effect, our case highlights the need to be vigilant for uncommon adverse events with commonly used drugs.
Keywords: Orthomyxoviridae, Oseltamivir, rhabdomyolysis
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