25 August 2018
: Case report
Improved Bowel Function in Patients with Spina Bifida After Bone Marrow-Derived Mononuclear Cell Transplantation: A Report of 2 Cases
Congenital defects / diseases
Nguyen Thanh Liem1ABCDEFG*, Vu Duy Chinh2ABCDEF, Nguyen Thi Thinh3BCDEF, Ngo Duy Minh3ABCDEF, Hoang Minh Duc1BCDEFDOI: 10.12659/AJCR.909801
Am J Case Rep 2018; 19:1010-1018
Abstract
BACKGROUND: Bowel dysfunction is observed in 42.2–71.2% of patients with spina bifida. Traditional treatments yield limited results. The objective of this paper is to report on improvement in bowel function in 2 children with spina bifida following bone marrow-derived mononuclear cells transplantation.
CASE REPORT: Two patients – 14 years old and 11 years old – with bowel dysfunction after myelomeningocele repair underwent 2 BMMNC transplantations without complications. Those patients had normal defecation, assessed through follow-ups of 21 months and 16 months, respectively.
CONCLUSIONS: BMMNC transplantation can improve bowel function, as demonstrated in 2 patients with spina bifida.
Keywords: adult stem cells, Bone Marrow Transplantation, Spina Bifida Occulta
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