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25 August 2018 : Case report  Vietnam

Improved Bowel Function in Patients with Spina Bifida After Bone Marrow-Derived Mononuclear Cell Transplantation: A Report of 2 Cases

Congenital defects / diseases

Nguyen Thanh Liem1ABCDEFG*, Vu Duy Chinh2ABCDEF, Nguyen Thi Thinh3BCDEF, Ngo Duy Minh3ABCDEF, Hoang Minh Duc1BCDEF

DOI: 10.12659/AJCR.909801

Am J Case Rep 2018; 19:1010-1018

Abstract

BACKGROUND: Bowel dysfunction is observed in 42.2–71.2% of patients with spina bifida. Traditional treatments yield limited results. The objective of this paper is to report on improvement in bowel function in 2 children with spina bifida following bone marrow-derived mononuclear cells transplantation.

CASE REPORT: Two patients – 14 years old and 11 years old – with bowel dysfunction after myelomeningocele repair underwent 2 BMMNC transplantations without complications. Those patients had normal defecation, assessed through follow-ups of 21 months and 16 months, respectively.

CONCLUSIONS: BMMNC transplantation can improve bowel function, as demonstrated in 2 patients with spina bifida.

Keywords: adult stem cells, Bone Marrow Transplantation, Spina Bifida Occulta

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923