03 September 2018 : Case report
Agranulocytosis Induced by Vancomycin. Case Report and Literature Review
Unusual or unexpected effect of treatment, Adverse events of drug therapyHoracio di Fonzo1ABCDEFG*, Melina Villegas Gutsch1BDF, Augusto Castroagudin1BF, María Victoria Cabrera1BF, Mariano E. Mazzei1ADF, Darío Rueda1ABDEF
Am J Case Rep 2018; 19:1053-1056
BACKGROUND: Vancomycin has been used for decades to treat infections by Gram-positive bacteria, particularly those caused by methicillin-resistant staphylococci. Agranulocytosis is an infrequent complication of this antibiotic, postulated in its genesis a mechanism immune-mediated by antineutrophil antibodies and antineutrophil cytoplasm antibodies (ANCA). Treatment includes discontinuing vancomycin, and granulocyte colony-stimulating factor administration.
CASE REPORT: We present the case of a patient who developed agranulocytosis secondary to vancomycin during the treatment of an infectious endocarditis, which was reversed when the antibiotic was stopped. Concomitantly to neutropenia, he had ANCA positivity, which subsequently became negative.
CONCLUSIONS: Agranulocytosis induced by vancomycin is infrequent and generally occurs after day 12 of treatment. In most cases, like in our case, it is caused by an immune-mediated mechanism. More studies are needed to determine the pathogenic mechanism and the ANCA role in this adverse effect.
Keywords: agranulocytosis, Antibodies, Antineutrophil Cytoplasmic, Vancomycin
29 March 2023 : EditorialEditorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...
Med Sci Monit In Press; DOI: 10.12659/MSM.940519
21 March 2023 : Case reportKidney Transplantation from a Deceased Donor with COVID-19 Ad26.COV2-S Vaccine-Induced Thrombotic Thrombocy...
Am J Case Rep In Press; DOI: 10.12659/AJCR.938730
21 March 2023 : Case reportClassical Presentation of Disseminated Blastomycosis in a 44-Year-Old Healthy Man 3 Months After Diagnosis ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.938659
22 February 2023 : Case reportA 30-Year-Old Woman with an 8-Week History of Anxiety, Depression, Insomnia, and Mild Cognitive Impairment ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.938732
30 Mar 2023 : Case reportAnterior Descending Coronary Artery Pseudoaneurysm in an 85-Year-Old Male Hemodialysis Patient: A Surgical ...
Am J Case Rep In Press; DOI: 10.12659/AJCR.939200
30 Mar 2023 : Case reportA 43-Year-Old Brazilian Man with Acute Impairment of Lung Function and Pulmonary Nodules with Features of E...
Am J Case Rep In Press; DOI: 10.12659/AJCR.939365
28 Mar 2023 : Case reportA Huge Malignant Ovarian Tumor: A Case Report
Am J Case Rep In Press; DOI: 10.12659/AJCR.939387
27 Mar 2023 : Case reportChest Tightness with Cycling Turned Out To Be Pneumomediastinum
Am J Case Rep In Press; DOI: 10.12659/AJCR.939170
Most Viewed Current Articles
06 Dec 2021 : Case reportLipedema Can Be Treated Non-Surgically: A Report of 5 Cases
Am J Case Rep 2021; 22:e934406
13 Jul 2022 : Case reportWhistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound
Am J Case Rep 2022; 23:e936441
23 Feb 2022 : Case reportPenile Necrosis Associated with Local Intravenous Injection of Cocaine
Am J Case Rep 2022; 23:e935250
07 Dec 2021 : Case reportEdwardsiella tarda: A Classic Presentation of a Rare Fatal Infection, with Possible New Background Risk Fac...
Am J Case Rep 2021; 22:e934347