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25 July 2018 : Case report  Brazil

Fatal Disseminated Kaposi’s Sarcoma in Two Patients with Human Immunodeficiency Virus (HIV) Infection

Unusual clinical course

Rafaela Barbirato Fardin1ABCDEF, Luiz Arhur Calheiros Leite2ABCDEF*, Luanna Mayara dos Santos Bezerra1B, Priscilla Maris Pereira Alves1CDEF, Layanne Lima dos Santos1BCD, Marília de Andrade Salvá1CDE, Antônio Luiz Soares Moura Rezende Filho1BCD, Gilberto Salustiano Lima2BD, Juliana de Amorim Matos1CD, Sônia Maria Soares Ferreira1B, Ducy Lily Joazeiro de Farias Costa1B

DOI: 10.12659/AJCR.910004

Am J Case Rep 2018; 19:868-874


BACKGROUND: Kaposi’s sarcoma (KS) is a common condition in patients with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). In these patients, the occurrence of KS is reduced by treatment with highly active antiretroviral therapy (HAART). Fatal and disseminated KS is presented in two patients with HIV/AIDS.

CASE REPORT: A 25-year-old man and a 30-year-old man with HIV/AIDS presented with KS affecting the skin, oral cavity, gastrointestinal tract, liver, lungs, kidneys, adrenal glands, and bone. Both patients had a rapidly deteriorating clinical course associated with a low CD4 count and developed respiratory failure and death.

CONCLUSIONS: Fatal disseminated KS is associated with severe immunosuppression due to with a low CD4 count. The presentation of these two cases highlights the potentially aggressive clinical course of KS in patients with HIV/AIDS and reinforces the need for early diagnosis and rapid treatment with HAART.

Keywords: Antiretroviral Therapy, Highly Active, HIV, Sarcoma, Kaposi

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923