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10 September 2018 : Case report  USA

A Case of Ocular Kaposi’s Sarcoma Successfully Treated with Highly Active Antiretroviral Therapy (HAART) Combined with Docetaxel

Mistake in diagnosis, Unusual or unexpected effect of treatment, Rare disease

Chongfei Jin12BCDEF*, Hamza Minhas3CDE, Amandeep Kaur1DEF, Sreenath Kodali3BC, Vladimir Gotlieb3AG

DOI: 10.12659/AJCR.910374

Am J Case Rep 2018; 19:1074-1077

Abstract

BACKGROUND: Ocular Kaposi’s sarcoma (KS) involving the conjunctiva and ocular adnexa is uncommon and is usually treated with cryotherapy or surgical excision. We report a case of ocular KS successfully treated with HAART combined with 8 cycles of weekly docetaxel.

CASE REPORT: Our patient was a 24-year-old, treatment-naïve, HIV-positive (CD4 cell count 198 cells/mm3), homosexual man treated as having atypical hordeolum and subconjunctival hemorrhage, and later confirmed with pathology to have ocular KS with immunohistochemistry study showing KS with positive HHV8, CD34, CD31, and focal positive staining with Factor VIIIRA. HAART therapy was initiated combined with weekly docetaxel. With 2-month treatment of HAART and 8 cycles of weekly docetaxel, the KS of the bulbar conjunctiva and the eyelid partially resolved.

CONCLUSIONS: HAART combined with weekly docetaxel is an effective and well-tolerated option for ocular KS, which could be considered before cryotherapy or surgical excision.

Keywords: Anti-Retroviral Agents, Herpesvirus 8, Human, Sarcoma, Kaposi

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923