Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

08 October 2018 : Case report  Japan

Eosinophilic Granulomatosis with Polyangiitis (EGPA) with an Unusual Manifestation of Mid-Ventricular Obstruction Caused by Endocardial Thrombus

Challenging differential diagnosis, Diagnostic / therapeutic accidents, Rare coexistence of disease or pathology

Takahide Ito1ABDEF*, Shu-ichi Fujita1BD, Yumiko Kanzaki1BD, Koichi Sohmiya1D, Masaaki Hoshiga1D

DOI: 10.12659/AJCR.910861

Am J Case Rep 2018; 19:1197-1203

Abstract

BACKGROUND: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis of unknown cause accompanied by prominent eosinophilia. Intracardiac thrombosis is one of the major cardiac complications in EGPA that may cause thromboembolism.

CASE REPORT: A 46-year-old male presenting with intermittent chest pain and numbness of the lower extremities was admitted to our center. His case was complicated by multiple brain infarcts and endocardial thrombosis in the left ventricle. A condition of restrictive cardiomyopathy was also found. After a thorough workup, he was diagnosed with antineutrophil cytoplasmic antibody (ANCA) positive EGPA. Interestingly, the thrombus was accompanied by a pressure gradient producing mid-ventricular obstruction. The patient improved reasonably with immunosuppression and anticoagulation treatment, in addition to heart failure treatment, and had a concomitant regression of the thrombus and reduction of the pressure gradient.

CONCLUSIONS: For an EGPA patient complicated by intraventricular obstruction caused by endocardial thrombosis, which could accelerate the release of the thrombus into the systemic circulation resulting in a life-threating condition, timely and aggressive measures against cardioembolic complications should be considered.

Keywords: Cardiomyopathy, Restrictive, Churg-Strauss syndrome, Echocardiography, Embolism and Thrombosis

Add Comment 0 Comments

In Press

Case report  Saudi Arabia

Corneal Ring Infiltrate Following Micropulse Cyclophotocoagulation

Am J Case Rep In Press; DOI: 10.12659/AJCR.945852  

Case report  Greece

Mesosigmoid Fossa Herniation: A Case of Jejunal Obstruction

Am J Case Rep In Press; DOI: 10.12659/AJCR.944817  

Case report  China

Right Bundle Branch Block on ECG as a Predictor of Sudden Cardiac Arrest Due to Pulmonary Embolism

Am J Case Rep In Press; DOI: 10.12659/AJCR.946074  

Case report  USA

A 20-Year-Old Woman with Metachronous Polyostotic Simple (Unicameral) Bone Cysts in 9 Sites: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.946165  

Most Viewed Current Articles

21 Jun 2024 : Case report  China (mainland) 89,036

Intracranial Parasitic Fetus in a Living Infant: A Case Study with Surgical Intervention and Prognosis Anal...

DOI :10.12659/AJCR.944371

Am J Case Rep 2024; 25:e944371

0:00

07 Mar 2024 : Case report  USA 50,209

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

20 Nov 2023 : Case report  Saudi Arabia 25,680

Azithromycin Treatment for Acne Vulgaris: A Case Report on the Risk of Clostridioides difficile Infection

DOI :10.12659/AJCR.941424

Am J Case Rep 2023; 24:e941424

0:00

18 Feb 2024 : Case report  Japan 22,688

A Case of Thoracic Empyema Caused by Actinomyces naeslundii

DOI :10.12659/AJCR.943030

Am J Case Rep 2024; 25:e943030

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923