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18 January 2019 : Case report  Italy

Tracheobronchopathia Osteochondroplastica: A Case Report Illustrating the Importance of Multilevel Workup Clinical, Endoscopic and Histological Assessment in Diagnosis of an Uncommon Disease

Rare disease

Giulio Riva1BDEF, Ilaria Girolami1DEF, Claudio Luchini1DE, Manuela Villanova1D, Giovanni Valotto1D, Luca Cima1D, Rodolfo Carella2ABD, Maurizio Riva2BD, Filippo Fraggetta3DE, Luca Novelli4DG, Albino Eccher1ADEG*

DOI: 10.12659/AJCR.911859

Am J Case Rep 2019; 20:74-77


BACKGROUND: Tracheobronchopathia osteochondroplastica (TO) is a rare idiopathic disease with a stable course, which involves the lumen of the tracheobronchial tree. Clinical manifestations at time of presentation may differ, typically including hoarseness, persistent and/or productive cough, hemoptyses, and dyspnea. There are no well-established guidelines for diagnostic workup and treatment. Our aim here is to present a paradigmatic case of TO together with a concise survey of the most important clinical, radiological, and histological criteria.

CASE REPORT: We report a case of a 62-year-old non-smoker male with persisting cough and no prior history of respiratory disease. Chest radiography (RX) and computed tomography (CT) were unremarkable. Given the persistence of symptoms, the patient underwent bronchoscopic examination, which revealed protruding sessile nodules into the tracheal lumen, with cobblestone appearance. Histopathological examination of biopsies taken during bronchoscopy showed cartilaginous and osseous submucosal nodules consistent with the diagnosis of TO.

CONCLUSIONS: TO is not always an easily recognized disease, and a multidisciplinary team work is often required for diagnosis, with particular importance of endoscopic-pathological correlation.

Keywords: Bronchoscopy, Osteochondrodysplasias, Tracheal Diseases, Cough

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923