Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

27 December 2018 : Case report  Japan

Development of Lobular Panniculitis Long After Completing the Personalized Peptide Vaccine Therapy

Unknown etiology, Mistake in diagnosis, Unusual or unexpected effect of treatment, Patient complains / malpractice, Adverse events of drug therapy

Aira Uchida1BDEF, Eiji Kawasaki1ADEF*, Masayuki Tojikubo1BD, Hidekazu Tamai1BD, Yoko Sagara1BD, Yuko Nakano1BD, Yoshitaka Uji2BD, Masanori Masuda3BD, Takahiro Yamaguchi4BD, Shigeru Yutani5BCD

DOI: 10.12659/AJCR.912418

Am J Case Rep 2018; 19:1530-1535

Abstract

BACKGROUND: Personalized peptide vaccine therapy is regarded as a well-tolerated, safe and effective immunotherapy for patients with advanced cancers. Herein we report an exceptional case of a patient with advanced pancreatic cancer who developed delayed lobular panniculitis at sites corresponding to vaccine injections.

CASE REPORT: A 64-year-old Japanese female visited our clinic due to thirst and polydipsia; she was diagnosed as having type 2 diabetes. Simultaneously, she was diagnosed as having advanced pancreatic cancer; and a distal pancreatectomy and splenectomy were performed. Afterwards, she received adjuvant chemotherapy with titanium silicate-1 and personalized peptide vaccination using Montanide® ISA-51 by a subcutaneous injection to her abdomen over a total of 30 times. Thirteen months after the vaccine therapy had come to an end, lobular panniculitis appeared at the vaccination sites. At this point, corticosteroid was administered, resulting in significant improvement in the condition of the subcutaneous nodules.

CONCLUSIONS: This case report highlights the importance of careful patient explanation before initiation of cancer vaccine therapy about the possibilities of lobular panniculitis as an adverse event. It also highlights that it is important that physicians have a greater awareness of the possibility of panniculitis in patients with concerns regarding subcutaneous indurations even long after the end of peptide vaccine therapy.

Keywords: Adjuvants, Immunologic, Cancer Vaccines, Drug-Related Side Effects and Adverse Reactions, Panniculitis

0 Comments

SARS-CoV-2/COVID-19

11 August 2022 : Case report  Japan

A 32-Year-Old Man with Persistent Olfactory Dysfunction Following COVID-19 Whose Recovery Was Evaluated by ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.936496  

09 August 2022 : Case report  Japan

A Case of Segmental Arterial Mediolysis of Multiple Visceral Arteries Following Anti-COVID-19 Vaccination: ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.937505  

29 July 2022 : Case report  Indonesia

Posterior Myocardial Infarction in a 45-Year-Old Javanese Woman with a 1-Month History of COVID-19-Related ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.937105  

08 July 2022 : Case report  Australia

Unusual Case of Painful Glossitis and Xerostomia Following Vaccination with Pfizer-BioNTech SARS-CoV-2 (BNT...

Am J Case Rep In Press; DOI: 10.12659/AJCR.937212  

In Press

17 Aug 2022 : Case report  Saudi Arabia

Musical Ear Syndrome in a Patient with Unilateral Hearing Loss: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.936537  

16 Aug 2022 : Case report  Hong Kong

Concurrent Bell’s Palsy and Facial Pain Improving with Multimodal Chiropractic Therapy: A Case Report and L...

Am J Case Rep In Press; DOI: 10.12659/AJCR.937511  

16 Aug 2022 : Case report  USA

Coronary Artery Stent Dislodgement and Loss in the Bloodstream: A Case Report and Management Options

Am J Case Rep In Press; DOI: 10.12659/AJCR.937598  

16 Aug 2022 : Case report  Saudi Arabia

A Pituitary Abscess Caused by Morganella morganii: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.936743  

Most Viewed Current Articles

13 Jul 2022 : Case report  USA

Whistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound

DOI :10.12659/AJCR.936441

Am J Case Rep 2022; 23:e936441

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

06 Dec 2021 : Case report  Brazil

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

17 Feb 2022 : Case report  Oman

Myocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...

DOI :10.12659/AJCR.934399

Am J Case Rep 2022; 23:e934399

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923