Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

25 February 2019 : Case report  USA

Clindamycin: An Unusual Cause of Acute Kidney Injury

Mistake in diagnosis, Unusual or unexpected effect of treatment, Adverse events of drug therapy

Pratima Subedi12ABEF, Ayesha Chowdhury12ABEF, Kristina Tanovic12BE, Igor Dumic12AEFG*

DOI: 10.12659/AJCR.913779

Am J Case Rep 2019; 20:248-251

Abstract

BACKGROUND: Medications are one of the most common causes of acute kidney injury (AKI). Elderly patients with diabetes mellitus and chronic kidney disease seem to be at particularly high risk for development of medication-induced AKI. Among antibiotics, the most commonly implicated agents are aminoglycosides, cephalosporins, trimethoprim-sulfamethoxazole, acyclovir, and amphotericin. Despite its widespread use, clindamycin has been rarely associated with AKI.

CASE REPORT: A 52-year-old male patient with type II insulin dependent diabetes mellitus without diabetic nephropathy was treated with clindamycin for chronic osteomyelitis. Five days following initiation of therapy, he developed nausea, poor appetite, decrease in urine output, and profound generalized weakness. His symptoms were initially attributed to gastrointestinal side effects of clindamycin and he was advised to take it with food and to hydrate himself vigorously. Despite this change, his symptoms progressed and he developed hematuria and AKI which prompted hospital admission. Extensive workup for AKI that included evaluation for pre-renal, intrinsic renal, and post-renal etiologies failed to point to other etiologies apart from clindamycin-induced AKI. Following cessation of medication and temporary renal replacement therapy (RRT), his renal function returned to baseline.

CONCLUSIONS: We present a case of clindamycin-induced AKI that was diagnosed after a delay due to uremia symptoms being mistakenly attributed to gastrointestinal side effects of clindamycin. Although rare, clindamycin can be a cause of AKI and clinician should be aware of this association in order to recognize and treat it in timely manner.

Keywords: Abnormalities, Drug-Induced, Acute Kidney Injury, clindamycin, Diabetes Mellitus, Type 2, Hematuria, Oliguria, Uremia, Anti-Bacterial Agents, osteomyelitis

Add Comment 0 Comments

In Press

Case report  Belgium

Late-Onset Hemophagocytic Lymphohistiocytosis in a Lung Transplant Patient: A Case of T-Cell Post-Transplan...

Am J Case Rep In Press; DOI: 10.12659/AJCR.944761  

Case report  Japan

Dantrolene for Control of Refractory Shivering in Severe Traumatic Brain Injury: A Case Study

Am J Case Rep In Press; DOI: 10.12659/AJCR.944980  

Case report  China

Precision Extraction of Lingual Mandibular Supernumerary Teeth Using Dynamic Navigation and High-Speed Hand...

Am J Case Rep In Press; DOI: 10.12659/AJCR.945262  

Case report  Lebanon

Anesthetic Strategies and Challenges in the Separation of Pygopagus Conjoined Twins: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.944776  

Most Viewed Current Articles

21 Jun 2024 : Case report  China (mainland) 59,306

Intracranial Parasitic Fetus in a Living Infant: A Case Study with Surgical Intervention and Prognosis Anal...

DOI :10.12659/AJCR.944371

Am J Case Rep 2024; 25:e944371

0:00

07 Mar 2024 : Case report  USA 42,927

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

10 Jan 2022 : Case report  Germany 32,489

A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV...

DOI :10.12659/AJCR.935263

Am J Case Rep 2022; 23:e935263

23 Feb 2022 : Case report  USA 20,116

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923