19 April 2019 : Case report
Verrucous Carcinoma of the Vulva: A Case Report and Literature Review
Mistake in diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Wei Zhang12BCDEFG, Yongyi Wang13D, Wei Chen14BD, Jingyun Du3D, Libing Xiang3A, Shuang Ye12B, Huijuan Yang12AC*DOI: 10.12659/AJCR.914367
Am J Case Rep 2019; 20:551-556
Abstract
BACKGROUND: Verrucous carcinoma (VC) of the vulva is a variation of squamous carcinoma (SCC). Etiology and treatment of VC are still unclear.
CASE REPORT: A 50-year-old female visited our clinic with a giant vulvar tumor (8 cm of diameter maximum). Biopsy revealed a suspicious well differentiation squamous cancer. PET/CT (positron emission tomography/computed tomography) scan found suspicious lymph node in bilateral iliac vessel region and bilateral inguinal region. She underwent radical vulvectomy and bilateral inguinal lymph node dissection, and bilateral pelvic lymph node dissection. Pathology turns out to be VC and no lymph nodes involvement. Due to the large defection, vulvar reconstruction was performed 5 weeks later using skin grafts and pudendal thigh flap. This patient was disease free after 12 months follow-up.
CONCLUSIONS: In patients with VC, a satisfactory biopsy is important and systemic inguinal lymphadenectomy might be omitted. For patients with large defection, flap-based reconstruction is recommended.
Keywords: Carcinoma, Squamous Cell, Carcinoma, Verrucous, Lymph Node Excision, Vulvar Neoplasms, Biopsy, Needle, Follow-Up Studies, Immunohistochemistry, Lymph Nodes, Positron Emission Tomography Computed Tomography, Reconstructive Surgical Procedures, Risk Assessment, Surgical Flaps, Vulvectomy
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