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25 July 2019 : Case report  Brazil

Antisynthetase Syndrome and Autoantibodies: A Literature Review and Report of 4 Cases

Challenging differential diagnosis, Unusual setting of medical care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Flávia Luiza Marin1ABCDEFG*, Henrique Pereira Sampaio2ABCDEFG

DOI: 10.12659/AJCR.916178

Am J Case Rep 2019; 20:1094-1103

Abstract

BACKGROUND: With the advent and advancement of autoantibodies, there has been progress in the diagnosis, prognosis, and treatment of rheumatologic diseases. Antisynthetase syndrome (ASS) is a great example of a disease that initially was described as arthritis, myositis, interstitial lung disease, mechanic’s hands, Raynaud’s phenomenon, and fever in the presence of the anti-JO-1 antibody, but nowadays it presents with a different spectrum related to new antibodies.

CASE REPORT: We describe 4 patients with antisynthetase syndrome who were diagnosed with antibodies specific for myositis associated with different clinical findings. All patients responded to immunosuppressive therapy, and rituximab was the most used.

CONCLUSIONS: It is necessary to search for specific autoantibodies related to the syndrome in suspected clinical cases and in other rheumatological diseases refractory to the usual treatment.

Keywords: Amino Acyl-tRNA Synthetases, Autoantibodies, myositis, Glucocorticoids, Immunosuppressive Agents, Methotrexate, Prednisone, Rare Diseases

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923