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30 July 2019 : Case report  Japan

Fluctuation of Hepatic Focal Nodular Hyperplasia Size with Oral Contraceptives Use

Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Unexpected drug reaction, Rare disease, Clinical situation which can not be reproduced for ethical reasons

Susumu Fukahori12ABD, Tetsuya Kawano13BDE, Yasushi Obase1CDEF*, Yasuhiro Umeyama12B, Nanae Sugasaki12D, Akitoshi Kinoshita12ABF, Chizu Fukushima1BF, Masaki Yamakawa4BCDF, Katsuhisa Omagari5ACD, Hiroshi Mukae1CDF

DOI: 10.12659/AJCR.916398

Am J Case Rep 2019; 20:1124-1127


BACKGROUND: Focal nodular hyperplasia (FNH) of the liver is a rare benign nodular lesion that arises in women of reproductive age. Although a role of female hormones has been suggested, their influence on the course of FNH has remained controversial.

CASE REPORT: A 44-year-old woman with a 12-year history of oral contraceptive use was referred to our hospital for examination of an asymptomatic liver mass (3 cm in diameter) identified by computed tomography. We diagnosed FNH using imaging methods and fine-needle biopsy. Oral contraceptives were discontinued because the mass increased over a period of 21 months. Four months later, the mass had decreased in size, indicating that FNH can spontaneously regress when oral contraceptives are discontinued.

CONCLUSIONS: Discontinuation of oral contraceptives use can reduce the size of FNH, as in this case.

Keywords: Contraceptives, Oral, Hormonal, Focal nodular hyperplasia, Gonadal Steroid Hormones, Contraceptives, Oral, Magnetic Resonance Imaging, Radionuclide Imaging, Tomography, X-Ray Computed

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923