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26 December 2019 : Case report  Japan

Long-Term Survival After Multidisciplinary Treatment Including Surgery for Metachronous Metastases of Small Intestinal Gastrointestinal Stromal Tumors after Curative Resection: A Case Report

Challenging differential diagnosis, Rare coexistence of disease or pathology

So Katayanagi1ABCDEF*, Takayoshi Yokoyama1B, Yousuke Makuuchi1B, Hiroaki Osakabe1B, Hitoshi Iwamoto1B, Tetsuo Sumi1B, Hiroshi Hirano2C, Kenji Katsumata3D, Akihiko Tsuchida3D, Seiichi Hirota4C, Shigeyuki Kawachi1D

DOI: 10.12659/AJCR.918606

Am J Case Rep 2019; 20:1942-1948


BACKGROUND: Currently, 3 molecular targeted drugs are available for the treatment of unresectable and recurrent gastrointestinal stromal tumors (GISTs), and result in improved prognoses and rare occurrence of bone metastases. However, there is no established treatment guideline for bone metastases of GIST.

CASE REPORT: The patient was a 56-year-old male who was diagnosed with leiomyosarcoma in 1997. Partial resection of the small bowel was performed. As part of post-operative follow-up in 2004, a computed tomography scan showed metastatic lesions in the liver and the right femoral neck. Accordingly, partial hepatectomy was performed, followed by artificial femoral head replacement. In 2006, bone metastases were detected in the sternum, cervical and thoracic vertebra, and the right upper arm; therefore, the patient was subjected to radiotherapy. However, further histopathological examination revealed positive findings for CD34+ and KIT cells, prompting a diagnosis of GIST. Imatinib was started. The disease remained stable. However, in 2010, metastasis to the right ilium was detected, after which there was an increase in metastatic lesions in the thoracic vertebra, prompting a diagnosis of progressive disease. Thus, treatment with sunitinib was initiated. In 2012, the patient experienced spinal paralysis due to metastasis in the eighth thoracic vertebra. In 2013, metastases in the right ilium, lungs, and liver were detected. In 2014, the patient died.

CONCLUSIONS: Multidisciplinary treatment via radiotherapy and surgery for GIST with bone metastases indicates the possibility of extending the overall survival further.

Keywords: Bone Diseases, gastrointestinal stromal tumors, Liver Diseases, Piezosurgery, Bone Neoplasms, Combined Modality Therapy, Fatal Outcome, Gastrointestinal Neoplasms, imatinib mesylate, Leiomyosarcoma, Liver Neoplasms, Middle Aged, Sunitinib

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923