Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

31 January 2020 : Case report  USA

Paraneoplastic Leukemoid Reaction in Gastroesophageal Junction Adenocarcinoma: A Case Report

Challenging differential diagnosis, Rare disease

Kevin Wei-Lun Chang1EF*, Lai Lai Kwok2EF, Manish K. Rana3EF, Sapna Patel4E, Thomas Birris5E

DOI: 10.12659/AJCR.919596

Am J Case Rep 2020; 21:e919596

Abstract

BACKGROUND: The presence of leukocytosis associated with non-hematological malignancy after ruling out other causes is defined as paraneoplastic leukemoid reaction (PLR). PLR is a rare manifestation of various solid tumors. It is associated with poor prognosis unless receiving effective antineoplastic treatments.

CASE REPORT: A 72-year-old female was referred to a hematologist/oncologist for the evaluation of leukocytosis with neutrophilia. Initial workup was unremarkable; however, she had progressively worsening leukocytosis with neutrophilia, associated with severe anemia and dysphagia. Computed tomography (CT) scan revealed wall thickening at the gastroesophageal junction (GEJ) and multiple hypodensities of the liver. Esophagogastroduodenoscopy (EGD) confirmed the diagnosis of GEJ tumor and biopsy returned as adenocarcinoma with human epidermal growth factor receptor 2 (HER2) overexpression. Leukocytosis resolved after the first round of chemotherapy and the patient remains progression-free with the addition of trastuzumab to her chemotherapy regimen.

CONCLUSIONS: We report a rare case of PLR caused by GEJ adenocarcinoma. This is the first case of PLR in a patient with metastatic GEJ adenocarcinoma with HER2 overexpression in the Caucasian population. It is important to workup leukocytosis promptly, to keep malignancy in the differential diagnosis and to seek early hematology/oncology consultation.

Keywords: Esophagogastric Junction, Genes, erbB-2, Leukemoid Reaction, Neoplasms, Paraneoplastic Syndromes, Adenocarcinoma, Aged, Drug Therapy, Combination, Endoscopy, Digestive System, Esophageal Neoplasms, Liver, Receptor, erbB-2, Trastuzumab

0 Comments

SARS-CoV-2/COVID-19

21 March 2023 : Case report  Croatia

Kidney Transplantation from a Deceased Donor with COVID-19 Ad26.COV2-S Vaccine-Induced Thrombotic Thrombocy...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938730  

21 March 2023 : Case report  USA

Classical Presentation of Disseminated Blastomycosis in a 44-Year-Old Healthy Man 3 Months After Diagnosis ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938659  

In Press

31 Mar 2023 : Case report  Germany

Successful Transplantation of a Liver from a Donor with HELLP Syndrome Undergoing Hypothermic Oxygenated Ma...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938131  

30 Mar 2023 : Case report  Japan

Anterior Descending Coronary Artery Pseudoaneurysm in an 85-Year-Old Male Hemodialysis Patient: A Surgical ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.939200  

30 Mar 2023 : Case report  Brazil

A 43-Year-Old Brazilian Man with Acute Impairment of Lung Function and Pulmonary Nodules with Features of E...

Am J Case Rep In Press; DOI: 10.12659/AJCR.939365  

28 Mar 2023 : Case report  Indonesia

A Huge Malignant Ovarian Tumor: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.939387  

Most Viewed Current Articles

06 Dec 2021 : Case report  Brazil

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

13 Jul 2022 : Case report  USA

Whistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound

DOI :10.12659/AJCR.936441

Am J Case Rep 2022; 23:e936441

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

07 Dec 2021 : Case report  USA

Edwardsiella tarda: A Classic Presentation of a Rare Fatal Infection, with Possible New Background Risk Fac...

DOI :10.12659/AJCR.934347

Am J Case Rep 2021; 22:e934347

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923