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03 March 2020 : Case report  Qatar

Acute Myeloid Leukemia Presenting with Numb Chin Syndrome: A Case Report and Review of Literature

Rare coexistence of disease or pathology

Mona M. Babikir1BDEFG*, Shehab F. Mohamed2BDEF, Abdulqadir J. Nashwan3BF, Deena S. Mudawi2BDF, Saleema C. Purayil1BDF, Mohamed Talaat Abdelrazek4DE, Khalid E. Ahmed1E, Mohamed A. Yassin2ABDEF

DOI: 10.12659/AJCR.920117

Am J Case Rep 2020; 21:e920117

Abstract

BACKGROUND: Numb chin syndrome is a rare and under diagnosed neuropathy of the inferior alveolar branch of the trigeminal nerve usually causing a lower lip and chin anesthesia or paresthesia. The syndrome is commonly associated with broad-spectrum malignant and non-malignant conditions.

CASE REPORT: Here we report a case of a 30-year-old male who presented with numb chin syndrome in the form of jaw pain, paresthesia, and hypoesthesia of the mental area as the presenting symptoms of acute of myeloid leukemia with t(8;21) treated with (3+7) protocol (3 days anthracycline+7 days cytarabine). The pain and paresthesia improved but hypothesia persisted.

CONCLUSIONS: Acute myeloid leukemia is one of the most serious causes of numb chin syndrome which should not be overlooked.

Keywords: Chin, Leukemia, Myeloid, Acute, Paresthesia, Antineoplastic Combined Chemotherapy Protocols, Hypesthesia, Syndrome

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923