BACKGROUND: Numb chin syndrome is a rare and under diagnosed neuropathy of the inferior alveolar branch of the trigeminal nerve usually causing a lower lip and chin anesthesia or paresthesia. The syndrome is commonly associated with broad-spectrum malignant and non-malignant conditions.

CASE REPORT: Here we report a case of a 30-year-old male who presented with numb chin syndrome in the form of jaw pain, paresthesia, and hypoesthesia of the mental area as the presenting symptoms of acute of myeloid leukemia with t(8;21) treated with (3+7) protocol (3 days anthracycline+7 days cytarabine). The pain and paresthesia improved but hypothesia persisted.

CONCLUSIONS: Acute myeloid leukemia is one of the most serious causes of numb chin syndrome which should not be overlooked.

Keywords: Chin, Leukemia, Myeloid, Acute, Paresthesia, Antineoplastic Combined Chemotherapy Protocols, Hypesthesia, Syndrome