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12 March 2020 : Case report  Greece

Postoperative Tetraplegia to a Child after Cerebellar Pilocytic Astrocytoma Excision at Prone Position: Case Report and Literature Review

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents

Dimitrios Panagopoulos1ABCDEF*, Elias Antoniades1ABCD, Ploutarchos Karydakis2BCDF, Dimitrios Giakoumettis3BCDE, Marios Themistocleous1ACDEF

DOI: 10.12659/AJCR.920213

Am J Case Rep 2020; 21:e920213

Abstract

BACKGROUND: Various factors have been implicated in the pathogenesis of infarction after posterior fossa surgery such as venous air embolism, patient’s position (seated or prone), hyperflexion of the neck, excessive spinal cord traction, cervical canal stenosis, and systemic arterial hypotension. The main aim of this case report was to elucidate a case in which hydrogen peroxide was implicated in a major and systemic complication after a neurosurgical procedure.

CASE REPORT: We describe the case of a 5-year-old female patient who was admitted to our hospital because of a cerebellar hemispheric astrocytoma associated with obstructive hydrocephalus and accompanied by 2 syringomyelic cavities in the cervicothoracic portion of the spinal cord. Immediately after gross total resection of the lesion, impaired mobility of the upper and lower extremities was observed, a finding that was not consistent with intraoperative neurophysiologic monitoring data. Hydrogen peroxide had been judiciously used to irrigate the resection tumor cavity. In the next few postoperative days, the patient suffered from transient diabetes insipidus and hyperpyrexia, indicative of hypothalamic injury.

CONCLUSIONS: Neurological evaluation of the patient, after stabilization of her medical condition, revealed residual spasticity of upper and lower extremities, rendering her able to mobilize via the aid of wheelchair only. The most possible pathophysiologic explanation of her neurological deterioration, including hypothalamic dysfunction, was analyzed. The role of hydrogen peroxide as a source of free radical formation, and its co-responsibility for vascular platelet aggregation and vasoconstriction was considered, upon case review, the main responsible etiologic factor.

Keywords: Brain Stem Infarctions, Diabetes Insipidus, Neurogenic, Hydrogen Peroxide, Infratentorial Neoplasms, Astrocytoma, Cerebellar Neoplasms, Child, Preschool, Hydrocephalus, Neurosurgical Procedures, Patient Positioning, Postoperative Complications, Prone Position, Quadriplegia

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923