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29 April 2020 : Case report  USA

Leiomyosarcoma Tumor Embolism Masquerading as Thrombus in Transit

Mistake in diagnosis, Rare disease

Benjamin L. Rosenfeld1ABCDEF*, Riyaz Bashir2AB, Meredith A. Brisco-Bacik2AB, Ioannis P. Panidis2AB, Anjali Vaidya2DE, Kenji Minakata3B, Paul R. Forfia2ABDEG

DOI: 10.12659/AJCR.921124

Am J Case Rep 2020; 21:e921124


BACKGROUND: Tumor embolism is a rare neoplastic complication that occurs when there is intravenous invasion by a benign or malignant tumor. We present the case of an asymptomatic patient with an incidentally discovered leiomyosarcoma tumor emboli, which was initially misdiagnosed as “thrombus in transit.”

CASE REPORT: The patient was a 58-year-old woman who was incidentally found on echocardiogram to have a large tubular mass within the inferior vena cava and right atrium. Although initially characterized as “thrombus in transit”, this mobile right atrial mass was present without clinical, echocardiographic, or radiographic evidence of pulmonary embolism or increased pulmonary arterial impedance. Given that a thrombus in transit is nearly always associated with submassive or massive pulmonary emboli and their attendant right heart sequelae, these pertinent negative findings led us to seek an alternative diagnosis. After a trial of conservative management with anticoagulation and attempted removal of the mass with the AngioVac system, the patient ultimately underwent median sternotomy and surgical embolectomy on cardiopulmonary bypass to remove the mass, which was later identified on pathology as a leiomyosarcoma.

CONCLUSIONS: With rare exceptions, “thrombus in transit” is accompanied by large pulmonary emboli and the presence of increased pulmonary artery pressure and right heart strain. The absence of clinical, echocardiographic, or radiographic evidence of these hemodynamic sequelae should raise suspicion for an alternative diagnosis. Tumor embolism should be considered in the differential diagnosis of any patient with a history of malignancy who presents with evidence of intracardiac mass or embolism.

Keywords: Neoplastic Cells, Circulating, Pulmonary Embolism, Ventricular Function, Right, Cardiopulmonary Bypass, Diagnosis, Differential, Embolectomy, Heart Atria, Incidental Findings, Leiomyosarcoma, Middle Aged, Pulmonary Artery, sternotomy, Thrombosis, Uterine Neoplasms


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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923