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30 March 2020 : Case report  Japan

Fatal Mumps Myocarditis Associated with Left Ventricular Non-Compaction

Challenging differential diagnosis, Management of emergency care, Patient complains / malpractice, Rare coexistence of disease or pathology

Leila Jemail1ABCDEF, Masashi Miyao1ABCDEF, Hideki Hamayasu1ABCD, Hirozo Minami1ABC, Hitoshi Abiru1ABC, Shiro Baba2CDE, Toshio Osamura3CDE, Keiji Tamaki1BCD, Hirokazu Kotani1ABCDEFG*

DOI: 10.12659/AJCR.921177

Am J Case Rep 2020; 21:e921177

Abstract

BACKGROUND: Myocarditis is a rare but potentially fatal complication of mumps virus infection. Left ventricular non-compaction (LVNC) is a rare congenital abnormality that can lead to development of low cardiac output, cardiac dysfunction, arrhythmias, or sudden cardiac death. To the best of our knowledge, no autopsy cases of mumps myocarditis with LVNC have been reported in the literature. Here, we report an autopsy case of a 21-month-old girl who died due to mumps myocarditis associated with an undiagnosed LVNC.

CASE REPORT: Postmortem computed tomography demonstrated bilaterally enlarged parotid glands. Serum analysis of anti-mumps IgM titer was positive. Macroscopic and histological examinations revealed glandular destruction with massive inflammatory cell infiltration of the enlarged parotid glands and mild inflammatory cell infiltration of the heart, which showed prominent trabeculations and deep intra-trabecular recesses, indicating LVNC. Immunohistochemical analyses showed positive immunostainings for mumps in the cardiac and salivary gland tissues.

CONCLUSIONS: These findings suggest that mumps myocarditis associated with LVNC contributed to this patient’s death. Myocarditis patients with other comorbidities, including LVNC, may be at higher risk of sudden death. Further reports of mumps myocarditis and LVNC are needed to better understand the mechanisms of sudden unexpected deaths in children.

Keywords: Autopsy, Comorbidity, Death, Sudden, Heart Defects, Congenital, Pediatrics, Vaccination, Death, Sudden, Cardiac, Fatal Outcome, Infant, mumps, myocarditis

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923