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14 March 2020 : Case report  Czech Republic

Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement

Unusual or unexpected effect of treatment, Rare disease

Heidi Mociková1ABDEF*, Hana Malikova2ABBDDEEFF, Michal Holesta2ABDE, Abdulfattah Elturki3ABDE, Vit Campr4DE, Tomas Kozak1ABDEFG

DOI: 10.12659/AJCR.921657

Am J Case Rep 2020; 21:e921657

Abstract

BACKGROUND: CNS involvement in Hodgkin lymphoma is rare. Despite various treatment options, median overall survival is only 13 months after diagnosis of CNS involvement in relapsed/refractory HL.

CASE REPORT: A 29-year-old woman with classical HL (mixed cellularity) in clinical stage IIB was treated with multilineage chemotherapy and radiotherapy without achieving a sustained complete remission. Systemic and CNS progression of HL occurred at the age of 32 years and the patient received 2 cycles of brentuximab vedotin with bendamustine alternating with 2 cycles of high-dose methotrexate-based treatment and achieved partial remission. She then underwent autologous stem cell transplantation followed by brentuximab vedotin consolidation. The disease progressed and the patient died 6 months after the last dose of brentuximab vedotin.

CONCLUSIONS: We demonstrated a durable response to brentuximab vedotin-based chemotherapy in a patient with refractory Hodgkin lymphoma with CNS involvement. Prognosis of these patients is poor and new treatment options are needed.

Keywords: Central Nervous System, Hodgkin Disease, Antineoplastic Combined Chemotherapy Protocols, Brentuximab Vedotin, Central Nervous System Neoplasms, Fatal Outcome, Positron Emission Tomography Computed Tomography, Salvage Therapy, Transplantation, Autologous

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923