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14 March 2020 : Case report  Czech Republic

Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement

Unusual or unexpected effect of treatment, Rare disease

Heidi Mocikov√°1ABDEF*, Hana Malikova2ABBDDEEFF, Michal Holesta2ABDE, Abdulfattah Elturki3ABDE, Vit Campr4DE, Tomas Kozak1ABDEFG

DOI: 10.12659/AJCR.921657

Am J Case Rep 2020; 21:e921657

Abstract

BACKGROUND: CNS involvement in Hodgkin lymphoma is rare. Despite various treatment options, median overall survival is only 13 months after diagnosis of CNS involvement in relapsed/refractory HL.

CASE REPORT: A 29-year-old woman with classical HL (mixed cellularity) in clinical stage IIB was treated with multilineage chemotherapy and radiotherapy without achieving a sustained complete remission. Systemic and CNS progression of HL occurred at the age of 32 years and the patient received 2 cycles of brentuximab vedotin with bendamustine alternating with 2 cycles of high-dose methotrexate-based treatment and achieved partial remission. She then underwent autologous stem cell transplantation followed by brentuximab vedotin consolidation. The disease progressed and the patient died 6 months after the last dose of brentuximab vedotin.

CONCLUSIONS: We demonstrated a durable response to brentuximab vedotin-based chemotherapy in a patient with refractory Hodgkin lymphoma with CNS involvement. Prognosis of these patients is poor and new treatment options are needed.

Keywords: Central Nervous System, Hodgkin Disease, Antineoplastic Combined Chemotherapy Protocols, Brentuximab Vedotin, Central Nervous System Neoplasms, Disease Progression, Fatal Outcome, Neoplasm Staging, Positron Emission Tomography Computed Tomography, Prognosis, Salvage Therapy, Transplantation, Autologous

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923