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01 April 2020 : Case report  Jordan

Successful Management of the First Case of a Metastasized Complete Mole in Form of Twin Pregnancy in Jordan

Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease, Adverse events of drug therapy , Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology

Amer Sindiani1ABCDEF*, Basil Obeidat1ABCD, Eman Alshdaifat2DEF

DOI: 10.12659/AJCR.923395

Am J Case Rep 2020; 21:e923395


BACKGROUND: A complete mole with a living fetus in a form of twin pregnancy that is a rare obstetric event. The development of metastatic gestational trophoblastic disease is the most important and serious complication. It is debatable whether to terminate the pregnancy or to continue. Another point is the validity of the conservative treatment of this type of neoplasm, especially in developing countries.

CASE REPORT: In this study, we report the first case of a twin pregnancy with complete mole and a living fetus in Jordan, which is a developing country. A 33-year-old woman presented with vaginal bleeding which was revealed to be due to a complete mole in the form of a twin pregnancy. A hystrostomy was performed with subsequent drop of β-hCG level. However, the β-hCG started to rise and the CT scan revealed multiple metastatic sites. Accordingly, she received 3 cycles of methotrexate, with a subsequent reduction in β-hCG level.

CONCLUSIONS: This is the first case report of a complete mole in twin pregnancy in Jordan. To overcome the development of metastasis, close follow-up and immediate treatment are crucial when the conservative approach is being considered. This report highlights the importance of considering the diagnosis of complete mole for women with twin and vaginal bleeding.

Keywords: gestational trophoblastic disease, Hydatidiform Mole, Neoplasm Metastasis, Twins, Antimetabolites, Antineoplastic, Combined Modality Therapy, Hysterotomy, Jordan, Methotrexate, Pregnancy, Pregnancy, Twin, Uterine Hemorrhage, Uterine Neoplasms


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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923