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13 August 2022 : Case report  Italy

Interleukin-6 Is a Promising Marker of COVID-19 in Children: A Case Series of 2 Brothers with Severe COVID-19 Pneumonia

Unusual clinical course, Challenging differential diagnosis, Unusual setting of medical care

Maria Cristina Maggio1ABCDEF*, Maria Concetta Failla2ABCDE, Salvatore Giordano2ABCD, Marco Pio La Manna3BC, Guido Sireci3ABCDEF

DOI: 10.12659/AJCR.934468

Am J Case Rep 2022; 23:e934468


BACKGROUND: To date, Coronavirus disease 2019 (COVID-19) remains a global health concern, with fatalities mostly in older age groups with underlying medical conditions, while children are less likely to manifest severe symptoms.

CASE REPORT: We describe the clinical cases of 2 brothers admitted to our Children’s Hospital for persistent fever and cough during the COVID-19 pandemic. Case 1. A 1.5-year-old boy had fever, expiratory dyspnea, desaturation, oxygen saturation 94-96% with O2, and bilateral hissing and crackling rales. His interleukin-6 level in the acute phase of the disease was 100.41 and at the resolution it was 46.2 pg/ml. Treatment with amoxicillin plus clavulanic acid, methylprednisolone, and O2 allowed progressive improvement of clinical conditions and laboratory data. Case 2. A 3-month-old toddler was admitted to our hospital for fever, cough, and tachypnea, which started 2 days before hospitalization. He had fever, cough, conjunctivitis, mucous rhinorrhea, and 99% oxygen saturation on room air. Thorax auscultation showed whistles and buzzes. He had a positive molecular test result from a COVID-19 swab. Interleukin-6 levels during all the phases of the disease were <6.25 pg/ml. The chest X-ray was normal. Treatment with azithromycin and methylprednisolone was followed by progressive improvement of clinical conditions.

CONCLUSIONS: These cases support the strong correlation between interleukin-6 levels and severe clinical manifestations such as COVID-19 pneumonia, and this marker predicts a more severe clinical outcome in children. Testing serum levels of interleukin-6 in children with COVID-19 could be useful to better understand the outcome of lung damage.

Keywords: bronchopneumonia, COVID-19, cytokine release syndrome, DAB(389)-Interleukin 6, Neutrophil Activation



11 August 2022 : Case report  Japan

A 32-Year-Old Man with Persistent Olfactory Dysfunction Following COVID-19 Whose Recovery Was Evaluated by ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.936496  

09 August 2022 : Case report  Japan

A Case of Segmental Arterial Mediolysis of Multiple Visceral Arteries Following Anti-COVID-19 Vaccination: ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.937505  

29 July 2022 : Case report  Indonesia

Posterior Myocardial Infarction in a 45-Year-Old Javanese Woman with a 1-Month History of COVID-19-Related ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.937105  

08 July 2022 : Case report  Australia

Unusual Case of Painful Glossitis and Xerostomia Following Vaccination with Pfizer-BioNTech SARS-CoV-2 (BNT...

Am J Case Rep In Press; DOI: 10.12659/AJCR.937212  

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16 Aug 2022 : Case report  USA

Coronary Artery Stent Dislodgement and Loss in the Bloodstream: A Case Report and Management Options

Am J Case Rep In Press; DOI: 10.12659/AJCR.937598  

16 Aug 2022 : Case report  Saudi Arabia

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Am J Case Rep In Press; DOI: 10.12659/AJCR.936743  

16 Aug 2022 : Case report  Poland

Stapedotomy in Congenital Stapes Ankylosis with Mobile Footplate: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.936466  

16 Aug 2022 : Case report  Germany

Percutaneous Left Atrial Appendage Closure with the LAmbre Device Protected by a Cerebral Protection System...

Am J Case Rep In Press; DOI: 10.12659/AJCR.937063  

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923