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13 September 2022 : Case report  Czech Republic

[In Press] Post-Injection Delirium/Sedation Syndrome: A Case Report and 2-Year Follow-Up

Unusual or unexpected effect of treatment, Adverse events of drug therapy

Gabriela Podgorná1ABCDEF, Jakub Albrecht2ABDE, Jozef Buday1BCDF, Tadeáš Mareš1EF, Thai Hong Le1F, Lucie Kališová1DF, Martin Anders1ACDEG

DOI: 10.12659/AJCR.937579

Am J Case Rep In Press; DOI: 10.12659/AJCR.937579  

Available online: 2022-09-13, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule

Abstract

BACKGROUND
Long-acting injectable (LAI) antipsychotics are one of the forms of therapy for severe mental illness. Post-injection delirium/sedation syndrome (PDSS) is a very rare but serious adverse effect following the application of an olanzapine in a long-acting form. The most common symptoms of the syndrome are sedation, delirium, dysarthria, ataxia, extrapyramidal symptoms, agitation, dizziness, or seizure. The predispositions, prevention, and exact mechanism of PDSS remain unclear.
CASE REPORT
We present a case report of a 30-year-old male patient experiencing PDSS, including the main symptoms of PDSS, diagnostic methods, olanzapine plasma concentrations, therapeutic process, and outcome. We then include a follow-up of the patient 2.5 years later. The patient did not have any long-term damage, had no disabilities, and no post-traumatic stress disorder following the event. We include information about his current medications, further use of LAI antipsychotics, and update about his everyday life.
CONCLUSIONS
PDSS is a life-threatening condition clinicians must be aware of, and the easiest precaution is a 3-h observation after the application of an injection. Because the predispositions, prevention, and exact mechanism of PDSS remains unclear, it is very important to report the rare cases of PDSS and conduct further research for the safety of our patients. The follow-up of the patient showed that the patient is doing well, he has no post-traumatic stress disorder following the event, and he did continue to use LAI antipsychotic medication.

Keywords: Drug-Related Side Effects and Adverse Reactions; Olanzapine; Schizophrenia

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Am J Case Rep In Press; DOI: 10.12659/AJCR.937147  

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Am J Case Rep In Press; DOI: 10.12659/AJCR.937834  

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26 Sep 2022 : Case report  Saudi Arabia

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Am J Case Rep In Press; DOI: 10.12659/AJCR.937695  

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Am J Case Rep In Press; DOI: 10.12659/AJCR.937581  

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Am J Case Rep In Press; DOI: 10.12659/AJCR.937259  

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923