Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

28 November 2022 : Case report  Saudi Arabia

Shoulder Metastasis: A Rare Nasopharyngeal Carcinoma Presentation

Challenging differential diagnosis, Rare coexistence of disease or pathology

Ameen Z. Alherabi ORCID logo12AEF*, Rehab F. Simsim3A, Suha H. Alsayed1ABE, Ahmad S. Alharthi4BE, Osama Marglani12BCD

DOI: 10.12659/AJCR.938123

Am J Case Rep 2022; 23:e938123


BACKGROUND: Nasopharyngeal carcinoma (NPC) is a rare malignant tumor that arises from the mucosal lining epithelium of the nasopharynx, most commonly at the lateral nasopharyngeal recess or fossa of Rosenmüller. According to global age-standardized incidence rates (ASIRs), in 2018 the incidence rate of nasopharyngeal carcinoma varied from 2.1 to 0.4 per 100 000 in Asia and Europe, respectively. The number of deaths exceeded 50 000. It is one of the few head and neck tumors prone to distant metastasis, most commonly to bones, lung, and liver.

CASE REPORT: In this case report, we present a rare case in which a 23-year-old male patient presented to our head and neck clinic. The patient presented initially to the orthopedic clinic with a right humeral mass lesion 10 cm with history of pain for the last 7 months. A Tru-Cut biopsy confirmed metastatic NPC. A nasopharyngeal biopsy further revealed his lesion to be an NPC undifferentiated type III. The patient was diagnosed with a T3 N2b M1 stage tumor and he was treated with chemoradiotherapy.

CONCLUSIONS: NPCs that present with a shoulder/humoral metastasis are very rare clinically. We are presenting this case to increase the awareness of the Otolaryngology – Head & Neck surgery, Orthopedic, and Oncology community of such a rare presentation.

Keywords: nasopharyngeal carcinoma, Shoulder



In Press

25 Nov 2022 : Case report  USA

A Case Report of Listeria Meningitis with Severe Rhabdomyolysis and Normal Renal Function

Am J Case Rep In Press; DOI: 10.12659/AJCR.938024  

24 Nov 2022 : Case report  Japan

Cardiac Arrest Following Torsades de Pointes Caused by Hypokalemia and Catecholamines in a Patient with Con...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938609  

24 Nov 2022 : Case report  Denmark

A Large Pericardial Cyst in the Left Cardiophrenic Causing Persistent Chest Pain and Cough: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.937785  

24 Nov 2022 : Case report  USA

Uterine Arteriovenous Malformation (AVM) – a Potentially Life-Threatening Cause of Post-Partum Vaginal Blee...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938559  

Most Viewed Current Articles

13 Jul 2022 : Case report  USA

Whistling Scrotum: An Unusual Presentation of Pneumomediastinum in the Setting of an Open Scrotal Wound

DOI :10.12659/AJCR.936441

Am J Case Rep 2022; 23:e936441

23 Feb 2022 : Case report  USA

Penile Necrosis Associated with Local Intravenous Injection of Cocaine

DOI :10.12659/AJCR.935250

Am J Case Rep 2022; 23:e935250

06 Dec 2021 : Case report  Brazil

Lipedema Can Be Treated Non-Surgically: A Report of 5 Cases

DOI :10.12659/AJCR.934406

Am J Case Rep 2021; 22:e934406

17 Feb 2022 : Case report  Oman

Myocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of P...

DOI :10.12659/AJCR.934399

Am J Case Rep 2022; 23:e934399

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923