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20 January 2023 : Case report  United Arab Emirates

[In Press] A 46-Year-Old Woman with a 4-Year History of Graves Disease, with Severe Corticosteroid-Unresponsive Thyroid Eye Disease, Successfully Treated with Tocilizumab

Unusual or unexpected effect of treatment

Ohood Almazrouei1ABCDEF, Fatima Alalawi2ABCDEF, Safiya Albrashdi2ABCDEFG, Hessah Alsharqi2ABCDEF, Ahmed Alsaadi2ACDEFG, Mondy Hammad1ABCDEF, Alain Sabri1ABCDEF, Habibullah Eatamadi1ABCDEFG

DOI: 10.12659/AJCR.938487

Am J Case Rep In Press; DOI: 10.12659/AJCR.938487  

Available online: 2023-01-20, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule


Tocilizumab is a therapeutic biologic antagonist of the interleukin-6 (IL-6) receptor that has been approved to treat some autoimmune and chronic inflammatory diseases. This report is of a patient with a history of Graves disease and severe corticosteroid-unresponsive thyroid eye disease that included edema of the optic nerve and choroid, which was successfully treated with tocilizumab.
A 46-year-old woman with a 4-year history of Graves disease presented with acutely progressive bilateral severe optic nerve compression, severe bilateral optic nerve edema, bilateral restriction of eye movement, and bilateral choroidal folds. The patient was managed with an initial high dose of systemic steroid without any success. She then underwent bilateral orbital wall decompression without any noticeable amelioration. She subsequently received 4 doses of a tocilizumab (8 mg/kg) infusion. This resulted in a considerable decrease in inflammatory signs and improvement in optic nerve function, thereby improving her quality of life. The patient did not have any adverse reactions to the tocilizumab.
The findings from this case support recent case reports and clinical trials indicating that tocilizumab may be effective in corticosteroid-resistant thyroid eye disease associated with autoimmune hyperthyroidism.

Keywords: Exophthalmos; Hyperthyroidism; Optic Nerve Diseases; Tocilizumab

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923