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06 March 2023 : Case report  Bulgaria

[In Press] Laparoscopic Treatment of Primary Colon Melanoma: A Case Study

Rare disease

Biser Petrov1ABCDE, Plamen Milanov Petrov2ABCDEF, Stoian Anguelov Alexov3ABCDE, Gyuner Hadzhiev1BCDE, Teodora Vukova4BCDEFG

DOI: 10.12659/AJCR.938914

Am J Case Rep In Press; DOI: 10.12659/AJCR.938914  

Available online: 2023-03-06, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule


Gastrointestinal tract melanomas are usually of metastatic origin, with primary melanomas being relatively rare. Controversy arises about the existence of primary melanoma in the gastrointestinal tract except in areas where melanocytes exist. The appearance of primary colon melanoma is rare due to the embryological absence of melanocytes in the large intestine, with some authors denying its existence at all.
We present a clinical case of a female patient with a primary melanoma of the descending colon. The patient came to the clinic with nausea without vomiting, abdominal swelling and pain, difficult and irregular defecation, and data on a tumor process of the left colon from the performed colonoscopy. Laparoscopic left hemicolectomy with lymphatic dissection was performed. The conclusion to be drawn from histological results was that the malignancy is poorly-differentiated adenocarcinoma. However, the immunohistochemical examination showed colon melanoma. Postoperative complete dermatological and ophthalmic examinations showed no evidence of a cutaneous or an ocular primary lesion, so we decided that this could be a primary colon melanoma.
Because of the colonoscopy we were able to make a detailed histological examination of the tumor, which allowed us to differentiate it from common colon adenocarcinomas. Surgical treatment is important in the removal of the primary tumor. The method of choice, with excellent postoperative results, is laparoscopic left hemicolectomy with selective cut-off of the colic vessels at the site of separation and removal of the affected segment together with the mesentery-bearing regional lymphatic basin.

Keywords: Histology, Comparative; Nevi and Melanomas; Colorectal Surgery; Colonoscopy


22 February 2023 : Case report  Taiwan

A 30-Year-Old Woman with an 8-Week History of Anxiety, Depression, Insomnia, and Mild Cognitive Impairment ...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938732  

22 February 2023 : Case report  Nigeria

Multidrug-Resistant Kocuria rosea and Methicillin-Resistant Staphylococcus aureus Co-Infection in a Nigeria...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938761  

In Press

17 Mar 2023 : Case report  USA

Dermoid Cyst of the Parotid Gland: Case Report of a Rare Entity and Review of the Literature

Am J Case Rep In Press; DOI: 10.12659/AJCR.939411  

17 Mar 2023 : Case report  Japan

A Case of a Refractory Bleeding Giant Vaginal Wall Cavernous Hemangioma Successfully Managed with Sclerothe...

Am J Case Rep In Press; DOI: 10.12659/AJCR.939474  

16 Mar 2023 : Case report  Indonesia

Initial Thrombocyte Concentrate Transfusion in Woman with Chronic Immune Thrombocytopenia Purpura (ITP) Who...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938752  

15 Mar 2023 : Case report  USA

Thoracic Epidural as a Rescue Analgesic in a Patient with a Continuous Erector Spinae Plane Block for Rib F...

Am J Case Rep In Press; DOI: 10.12659/AJCR.938875  

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923