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13 September 2023 : Case report  China (mainland)

[In Press] Exploring the ECG “6+2” Phenomenon in Coronary Artery Disease and Coronary Artery Spasm: A Case Report Analysis and Treatment Implications

Unusual clinical course, Educational Purpose (only if useful for a systematic review or synthesis)

Hongyang Zhang12ABCDEF, Peng Wang2ABCDEF, Zhen Duan2ABCDEF, Yao Ma3CDEF, Meiting Gong24ABCDEF, Haifeng Pei2ABCDEFG

DOI: 10.12659/AJCR.941692

Am J Case Rep In Press; DOI: 10.12659/AJCR.941692  

Available online: 2023-09-13, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule


Although coronary artery disease and coronary artery spasm (CAS) can lead to acute myocardial infarction, there are clear differences in treatment between coronary heart disease and CAS, and the therapeutic schedule should not be confused. Furthermore, electrocardiogram (ECG) “6+2” phenomenon is recommend as a specific ECG indicator for lesions in the left main coronary artery or multiple vessels. Currently, no reports of this phenomenon in CAS exist.
A 72-year-old man had history of recurrent chest pain for over 6 years, with episodes lasting about 10 min and resolving with rest. He experienced symptom recurrence and exacerbation due to substance abuse. He was admitted to our Emergency Department for chest pain at rest. His emergency ECG revealed a 6+2 phenomenon, accompanied by troponin levels exceeding 18 times the reference value. Promptly, we conducted coronary angiography, with unexpected normal findings. Following thorough assessment, we postulated the patient could have CAS. Subsequent to medical team intervention, the patient’s ECG normalized, leading to his discharge upon condition stabilization.
We report a case of CAS in a patient with ECG 6+2 phenomenon, without significant coronary artery stenosis. This differs from transient ST-segment elevation on ECG, a well-recognized hallmark of CAS; however, such a presentation has not been documented before. Additionally, treatment strategies for myocardial ischemic conditions stemming from coronary atherosclerosis diverge from those employed for CAS. Therefore, clinicians should advocate for coronary angiography whenever feasible. This approach serves to elucidate the underlying disease etiology and facilitates the administration of precision-targeted interventions for patients.

Keywords: Coronary Angiography; Coronary Disease; Coronary Vasospasm; Electrocardiography; Myocardial Infarction

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Surgical Treatment of a Neglected Thumb Volar Plate Injury in an 11-Year-Old Girl: A Case Report

Am J Case Rep In Press; DOI: 10.12659/AJCR.940411  

28 Sep 2023 : Case report  Greece

Ileocolic Intussusception in Infancy is not Always Idiopathic – Adenomyoma as the Leading Point

Am J Case Rep In Press; DOI: 10.12659/AJCR.939789  

27 Sep 2023 : Case report  USA

Life-Threatening Cardiac Arrhythmias in a Case of Undetected Myxedema Coma: Importance of Early Detection a...

Am J Case Rep In Press; DOI: 10.12659/AJCR.941414  

26 Sep 2023 : Case report  Kuwait

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Am J Case Rep In Press; DOI: 10.12659/AJCR.940966  

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923