27 April 2024 : Case report
[In Press] Genome Sequencing Analysis of a Rare Case of Blood Infection Caused by Flavonifractor plautii
Challenging differential diagnosis, Management of emergency care, Patient complains / malpractice, Unexpected drug reaction, Rare disease, Clinical situation which can not be reproduced for ethical reasons
Xingying Chen1ABCD, Wei Bi1ABCDE, Xinyi Ruan2AB, Limin Jin1ABEFG, Nenghua Zhang1ABCDEFGDOI: 10.12659/AJCR.943920
Am J Case Rep In Press; DOI: 10.12659/AJCR.943920
Available online: 2024-04-27, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
Abstract
BACKGROUND
Flavonifractor plautii belongs to the clostridium family, which can lead to local infections as well as the bloodstream infections. Flavonifractor plautii caused infection is rarely few in the clinic. To understand better Flavonifractor plautii, we investigated the drug sensitivity and perform genome sequencing of Flavonifractor plautii isolated from blood samples in China and explored the drug resistance and pathogenic mechanism of the bacteria.
CASE REPORT
The Epsilometer test method was used to detect the sensitivity of flavonoid bacteria to antimicrobial agents. PacBio sequencing technology was employed to sequence the whole genome of Flavonifractor plautii, and gene prediction and functional annotation were also analyzed. Flavonifractor plautii displayed sensitivity to most drugs but resistance to fluoroquinolones and tetracycline, potentially mediated by tet (W/N/W). The total genome size of Flavonifractor plautii was 4,573,303 bp, and the GC content was 59.78%. Genome prediction identified 4,506 open reading frames, including 9 ribosomal RNAs and 66 transfer RNAs. It was detected that the main virulence factor-coding genes of the bacteria were the capsule, polar flagella and FbpABC, which may be associated with bacterial movement, adhesion, and biofilm formation.
CONCLUSIONS
The results of whole-genome sequencing could provide relevant information about the drug resistance mechanism and pathogenic mechanism of bacteria and offer a basis for clinical diagnosis and treatment.
Keywords: Flavonifractor plautii; pathogenesis-related proteins, plant; Whole Genome Sequencing
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