Logo American Journal of Case Reports

Call: 1.631.629.4328
Closed: National Holiday

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

13 February 2025 : Case report  Belgium

A 37-Year-Old Man with Multifocal Bilateral Malignant Testicular Large-Cell Calcifying Sertoli Cell Tumors Presenting as Painless Testicular Masses

Unusual clinical course, Challenging differential diagnosis, Rare disease

Lukas Dohmen1ABDEF*, Mélissa Pani2ADEF, Pierre Marchettini1EF, François Devos2AE

DOI: 10.12659/AJCR.945910

Am J Case Rep 2025; 26:e945910

Abstract

0:00

BACKGROUND: Large-cell calcifying Sertoli cell tumor (LCCSCT) belongs to the category of sex cord stromal tumors and is extremely rare. Testicular LCCSCTs show benign or malignant behavior, appear sporadically, or are associated with genetic syndromes. Benign LCCSCTs are more commonly bilateral and multifocal and present in younger patients. The prognosis is poor when patients have advanced or metastatic disease. However, due to its rarity, the literature provides only weak evidence concerning their clinical course and treatment options. This report describes a 37-year-old man suffering from a multifocal, bilateral malignant testicular LCCSCT presenting as painless testicular masses.

CASE REPORT: A 37-year-old man presented with bilateral painless testicular masses. Imagery showed bilateral macro-orchitis with multifocal intratesticular hyperechoic and hypointense lesions. He underwent testis-sparing surgery with the enucleation of 1 testicular lesion. The anatomopathological analysis revealed an LCCSCT whose histological characteristics indicated a benign tumor. A simple follow-up was therefore recommended. Six years after diagnosis, the patient developed lymph node metastases, and radical bilateral orchiectomy and radical lymphadenectomy were performed. A few months later, pleural, pulmonary, and bone metastases occurred. Chemotherapy and immunotherapy did not control the disease. The patient died 7 years after the initial diagnosis.

CONCLUSIONS: This case highlights the importance of the histopathology diagnosis in cases of testicular masses, and that sporadic, multifocal, and bilateral LCCSCTs present in younger men can be malignant despite the benign characteristics of the primary tumor.

Keywords: Orchiectomy, Sertoli Cell Tumor, Testicular Neoplasms, Testis, Testicular Diseases

Add Comment 0 Comments

In Press

Case report  China

Emergency Management of Cut Throat Injury: A Report of 2 Cases

Am J Case Rep In Press; DOI: 10.12659/AJCR.946414  

Case report  Grenada

Extragastrointestinal Stromal Tumor Mimicking Appendicitis: A Case Study

Am J Case Rep In Press; DOI: 10.12659/AJCR.944665  

Case report  China

Vision-Threatening Complications of Juxtapapillary Retinal Capillary Hemangioma: A Case of Retinal Artery O...

Am J Case Rep In Press; DOI: 10.12659/AJCR.946514  

Case report  USA

Treatment of Post-COVID-19 Pulmonary Aspergilloma: Insights from a Clinical Case

Am J Case Rep In Press; DOI: 10.12659/AJCR.946456  

Most Viewed Current Articles

21 Jun 2024 : Case report  China (mainland) 90,010

Intracranial Parasitic Fetus in a Living Infant: A Case Study with Surgical Intervention and Prognosis Anal...

DOI :10.12659/AJCR.944371

Am J Case Rep 2024; 25:e944371

0:00

07 Mar 2024 : Case report  USA 50,284

Neurocysticercosis Presenting as Migraine in the United States

DOI :10.12659/AJCR.943133

Am J Case Rep 2024; 25:e943133

0:00

20 Nov 2023 : Case report  Saudi Arabia 25,908

Azithromycin Treatment for Acne Vulgaris: A Case Report on the Risk of Clostridioides difficile Infection

DOI :10.12659/AJCR.941424

Am J Case Rep 2023; 24:e941424

0:00

18 Feb 2024 : Case report  Japan 22,715

A Case of Thoracic Empyema Caused by Actinomyces naeslundii

DOI :10.12659/AJCR.943030

Am J Case Rep 2024; 25:e943030

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923