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10 April 2025 : Case report  China

[In Press] Non-Adjacent Bilateral Postherpetic Neuralgia in a Multiple Myeloma Patient: A Case Report

Unusual clinical course, Rare disease

Hua Zhang ORCID logo1BE, Jie He1AB, Zhongju Du1BCF, Jie Zhou1BC, Jurong Xia1AF

DOI: 10.12659/AJCR.946562

Am J Case Rep In Press; DOI: 10.12659/AJCR.946562  

Available online: 2025-04-10, In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule

Abstract

BACKGROUND
Postherpetic neuralgia is a refractory neuropathic pain that persists after healing from an acute herpes zoster infection. The pain is often perceived as a sensation akin to needling, cauterization, or electric shock. Clinically, it often manifests with unilateral onset, whereas patients with different sides and multiple segments of postherpetic neuralgia have not yet been reported. Owing to the incompletely elucidated pathogenesis, the therapeutic effects of currently available treatments in different patients are heterogenous, resulting in enormous pain. The risk factors for PHN include age >60 years, malignant tumors, diabetes, and immune dysfunction.
CASE REPORT
We report a case of a 65-year-old man with multiple myeloma who developed left T3 and right T11 postherpetic neuralgia. We used drugs as the basic treatment and then combined nerve pulse radio frequency, nerve block, and other treatments. After discharge, we followed up the patient for 3 months, gradually reducing the dose to wean the patient off the drug treatment, and intermittent pain occasionally occurred. The numerical rating scale score was 0-1 points, which is pain that does not affect daily activities or sleep.
CONCLUSIONS
We report a rare case of postherpetic neuralgia with multiple myeloma occurring on different sides, but not on adjacent nerve segments. We performed left T3 and right T11 nerve pulse radiofrequency surgery, after poor drug treatment efficacy, followed by postoperative nerve block therapy; then, the patient’s pain had been effectively controlled. We hope that our case can provide reference for doctors who encounter similar cases in the future.

Keywords: Multiple Myeloma; Neuralgia, Postherpetic; Neurology

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923