09 April 2025
: Case report
[In Press] Isopropyl Alcohol in Bleb Revision: A Novel Approach for Aesthetic and Functional Success
Unusual setting of medical care
Dania Bamefleh

DOI: 10.12659/AJCR.946949
Am J Case Rep In Press; DOI: 10.12659/AJCR.946949
Available online: 2025-04-09, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
Abstract
BACKGROUND
Overhanging filtering blebs (OFB) are a known complication of trabeculectomy, leading to visual disturbances, discomfort, and cosmetic concerns. Their management remains challenging, with high recurrence rates despite surgical interventions. This case report presents the clinical course, management, and outcome of an 18-year-old woman with an OFB who underwent bleb revision incorporating isopropyl alcohol as an adjunctive measure.
CASE REPORT
An 18-year-old woman with a history of trabeculectomy and prior bleb revision presented with a large, cystic, overhanging filtering bleb that extended toward the cornea, causing cosmetic concerns and discomfort. Her best-corrected visual acuity (BCVA) was 20/100 in the affected eye, and an intraocular pressure (IOP) was 8 mmHg. She underwent surgical revision involving bleb excision, conjunctival reapproximation, and application of 70% isopropyl alcohol to de-epithelialized corneal tissue to reduce the risk of recurrence. Postoperatively, the bleb was well formed, IOP remained stable at 10 mmHg without any IOP-lowering medications, and the patient reported significant cosmetic improvement. No complications or recurrences were observed at the 1-year follow-up.
CONCLUSIONS
This case highlights a potential role for isopropyl alcohol in the surgical revision of OFB. The technique was associated with a favorable functional and cosmetic outcome. Further studies are warranted to assess its long-term efficacy and broader applicability in glaucoma surgery.
Keywords: Glaucoma; Surgical Procedures, Operative; Filtering Surgery; Cosmetics
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