09 March 2020
: Case report 
Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Mantle Cell Lymphoma; Small Cell Variant: A Real Diagnostic Challenge. Case Presentation and Review of Literature
Challenging differential diagnosis, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Feryal Ibrahim ACDEF 1, Ahmad Al Sabbagh F 1, Aliaa Amer BDEF 2, Dina S. Soliman CEF 1,3*, Hesham Al Sabah AE 4DOI: 10.12659/AJCR.921131
Am J Case Rep 2020; 21:e921131
| Ref # | No of cases | Sex/age (yr) | Blood findings | BM findings | BM infiltration pattern | LN findings | LN infiltration pattern | MCL morphology |
|---|---|---|---|---|---|---|---|---|
| 8 | 1 | F/69 | CLL: Main cloneMCL: Small clone | ND | – | CLL and MCL | CLL: DiffuseMCL: Nodular | Medium size lymphocytes with irregular nucleus |
| 9 | 1 | M/86 | CLL: 90%MCL: 10% | CLL: 59%MCL: 27% | Nodular and interstitial | CLL: 10%MCL: 90% | NM | Large, less condensed chromatin, nucleoli |
| 10 | 1 | M.73 | CLL only | CLL only | Mild infiltration (15%) | CLL and MCL | Diffuse | Small lymphocytes |
| 11 | 1 | F/84 | CLL: 10%MCL: 30% | MCL & CLL | Nodular and interstitial | No LN | No LN | Small to medium lymphocytes |
| 12 | 7 CLL/MCL | M/6, F/1 55–80 | Not detailed | Not detailed | CLL: Not detailedMCL: Nodular(1/7) | CLL and MCL (6/7) | CLL: Internodular (6/7)MCL: (1), Mantle zone (1), Nodular and diffuse (1), diffuse (3) | Small lymphocytes (4), blastoid (3) |
| 12 | 4 SLL/MCL | Not detailed | M (4)69–79 | Not detailed | SLL: Internodular (2), Diffuse (1), Nodular (1)MCL: Nodular and diffuse (2), Focal (1), Mantle zone (1) | Small lymphocytes (1), blastoid (3) | ||
| Current case | 1 | M/57 | CLL: 12%MCL: 58% | CLL: 10%MCL: 59% | MCL: InterstitialCLL: Nodular and interstitial | ND | ND | Small cell variant |
| M – Male; F – Female; LN – lymph node; PB – peripheral blood; NM – not mentioned; ND – not done; CLL – chronic lymphocytic leukemia; MCL – mantle cell lymphoma; * One case with bone marrow involvement only. | ||||||||