20 December 2020: Articles
A Case of Malaria Treated with Artesunate in a 55-Year-Old Woman on Return to Florida from a Visit to Ghana
Management of emergency care
Jose A. Rodriguez A* , Alejandra A. Roa B , Ana-Alicia Leonso-Bravo B , Pratik Khatiwada B , Paula Eckardt G , Juan Lemos-Ramirez DDOI: 10.12659/AJCR.926097
Am J Case Rep 2020; 21:e926097
Table 2. Antimalarial therapy.
| Treatment | Dosing | Duration |
|---|---|---|
| Artesunate | Intravenous (IV): 2.4 mg/kg/dose at 0, 12, and 24 h; then 2.4 mg/kg once daily | Depends on parasitemia: |
| Quinidine gluconate | IV: Initially 6.25 mg base/kg (10 mg salt/kg) loading dose over 1–2 hThen 0.0125 mg base/kg/min (0.02 mg salt/kg/min) infusion over 24 h until tolerating oral intake | Tolerating oral intake: switch to oral therapyNot tolerating oral intake: continue quinidine for 3–7 days depending on where malaria was acquired:Must be given with 7 days total of doxycycline or clindamycin |
| Quinine sulfate | Oral: 2 capsules (542 mg base=648 mg salt) 3 times daily | 3–7 days depending on where malaria was acquired:Must be given with 7 days total of doxycycline or clindamycin |
| Doxycycline | IV and oral: 100 mg twice daily | 7 days |
| Clindamycin | IV: 10 mg base/kg for 1 dose (maximum 900 mg) followed by 15 mg base/kg/day in 3 equal doses (maximum 1350 mg)Oral: 20 mg base/kg/day in 3 equal doses (maximum 1800 mg) | 7 days |
| Atovaquone-Proguanil | Oral: 4 adult tabs once daily (250–100 mg per tab) | 3 days |
| Mefloquine | Oral: 684 mg base (750 mg salt) initial dose followed by 456 mg base (500 mg salt) 6–12 h after initial (total dose 1250 mg salt) | 1 day |