12 November 2020: Articles
Possible Azithromycin-Induced Life-Threatening Arrhythmia Requiring Extracorporeal Membrane Oxygenation Support: A Case Report
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease, Adverse events of drug therapy
Abdulrazaq S. Al-Jazairi A* , Haifa S. Alotaibi ADOI: 10.12659/AJCR.926951
Am J Case Rep 2020; 21:e926951
Table 1. Reported onset and offset of QT prolongation induced by azithromycin.
| Case | Administration route | Time to QT prolongation onset | Time to offset |
|---|---|---|---|
| Samarendra et al. 2001 []5 | Oral | 3 days | Day 4 after discontinuation |
| Kezerashvili et al. 2007 []6 | Oral | 7 days | Same day of discontinuing |
| Huang et al. 2007 []7 | Not reported | 4 hours | One day |
| Del Rosario et al. 2010 []8 | Not reported | Unknown | Patient died on day 3 before QT interval normalizes |
| Yazdan-Ashoori et al. 2012 []9 | Intravenous | 2 days | Not reported |
| Winton and Twilla, 2013 []10 | Not reported | 3 days | Not reported but patient improved and left ICU after 12 days |