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14 December 2020: Articles

A 23-Year-Old Man with SARS-CoV-2 Infection Who Presented with Auditory Hallucinations and Imaging Findings of Cytotoxic Lesions of the Corpus Callosum (CLOCC)

Unusual clinical course

Walid Elkhaled A* , Fatma Ben Abid A , Naveed Akhtar B , Mohamed R. Abukamar B , Wanis H. Ibrahim B

DOI: 10.12659/AJCR.928798

Am J Case Rep 2020; 21:e928798

Table 2. A Summary of individual cases reporting CLOCC in context of SARS-CoV-2 infection.

Author(s)Age/SexClinical presentationConfirmed SARS-CoV-2 serology/RT-PCRMRI findingsOutcome
Kakadia Do et al. []15 69/MDisorientation, inattention, bradyphrenia, feverElevated SARS-CoV-2 IgM and IgG antibodiesHyperintensity in SCCComplete resolution of neurological symptoms and corpus callosum lesion after 2 weeks
Agarwa et al. []16 73/MAltered consciousness, fever, and respiratory distressPCR positive for SARS-CoV-2Isolated lesion in SCCImproved and stepped down from ICU after 4 weeks. No documentation about resolution of corpus callosum lesion or neurological status follow-up
Hayashi et al. []17 75/MAltered sensorium, tremors, ataxia, and urinary incontinencePCR positive for SARS-CoV-2Abnormal hyperintensity in SCCNeurological symptoms resolved after 3 days. Patient died after 12 days secondary to respiratory failure
Moreau et al. []18 26/MAcute confusion, agitation, inappropriate speech, fever, dry coughPositive SARS-CoV-2 IgGHyperintense round lesion in SCCNeurological status improved within 48 h and his cardiac dysfunction resolved within 1 week. Follow-up MRI showed resolution of the corpus callosum lesion
Forestier et al. []7 55/MHeadache, high-grade fever, dizziness and impaired consciousnessPCR positive for SARS-Cov-2Increased diffusion-weighted signal in SCCImproved and extubated 17 days later, follow up MRI showed complete regression of the corpus callosum lesion
CLOCC – cytotoxic lesions of corpus callosum; SCC – splenium of corpus callosum; RT-PCR – real-time reverse transcription polymerase chain reaction test; SARS-CoV-2 – severe acute respiratory syndrome coronavirus 2.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923