12 August 2021: Articles
Hepatotoxicity Induced by Fluvastatin: A Reversible Acute Cholestatic Liver Injury
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Adverse events of drug therapy
Najah S. Alanazi A , Tahani S. Alenazi A , Khalidah A. Alenzi A*DOI: 10.12659/AJCR.931418
Am J Case Rep 2021; 22:e931418
Table 1. Patient laboratory values.
| Test | Date | Normal range | ||||
|---|---|---|---|---|---|---|
| On admission | After 1 Week | After 4 Weeks | After 6 Weeks | After 3 Months | ||
| 21/1/2013 | 28/1/2013 | 19/2/2013 | 4/3/2013 | 6/4/2013 | ||
| ALT | 107.8↑ | 158↑ | 83↑ | 49↑ | 11.3 | 10–45 U/L |
| AST | 202.7↑ | 152↑ | 87↑ | 58↑ | 26 | 10–45 U/L |
| ALP | 1200↑ | 1543↑ | 1138↑ | 329↑ | 280↑ | 40–100 U/L |
| GGT | – | 1350↑ | 716↑ | 130↑ | 60↑ | 11–49.4 U/L |
| CPK | 4200 | 3230 | 2900 | – | 670 | 60–400 U/L |
| BILD | 252.5↑ | 276.3↑ | 319.5↑ | 360↑ | 37.3↑ | ≤54 µmol/L |
| BILT | 318.2↑ | 332.5↑ | 393.1↑ | 177↑ | 39.4↑ | 0–21 µmol/L |
| TP | 62.9↓ | 61↓ | 62↓ | 62↓ | 63.2↑ | 65–81 g/L |
| Na | 124.4↓ | 133↓ | 132 I | 141 | 130↓ | 135–155 mmol/L |
| ALB | 19.05↓ | 10↓ | 13↓ | 23↓ | 21.8↓ | 28–46 g/L |
| CREA | 25↓ | 192↑ | 235↑ | 411↑ | 170↑ | 53–115 µmol/L |
| K | 3.94 | 4.2 | 4.3 | 3.1↓ | 4.3 | 3.6–5.5 mmol/L |
| Glucose | 14.2↑ | 9.75↑ | 13.02↑ | 14.4↑ | 12.3↑ | 4.1–5.9 µ mol/L |
| Ionized calcium | 4.1 | – | – | 3.6 | 3.4 | 4.5–5.6 mg/dL |
| Vitamin D | 26 | – | – | – | 20 | 20–0 ng/mL |
| INR | 1.1 | 1.1 | 1.1 | 1.3↑ | 1.2↑ | 0.9–1.1 s |
| PT | – | 14.55 | 14.5 | 16.6↑ | 14.6↑ | 12.3–14.2 s |
| PTT | 37.7s | 40.6 | 37.7↑ | 43.8↑ | 40.2↑ | 31.4–38.2 s |
| ALT – alanine aminotransferase; AST – aspartate transferase; ALP – alkaline phosphatase; GGT – Gamma-glutamyl transpeptidase; CPK – creatine phosphokinase; BILD – bilirubin, direct; BILT – bilirubin, total; TP – protein, total; Na – sodium; ALB – albumin; CREA – creatinine; K – potassium; INR – international normalized ratio; PT – prothrombin time; PTT – partial thromboplastin time. | ||||||