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12 August 2021: Articles

Hepatotoxicity Induced by Fluvastatin: A Reversible Acute Cholestatic Liver Injury

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Adverse events of drug therapy

Najah S. Alanazi A , Tahani S. Alenazi A , Khalidah A. Alenzi A*

DOI: 10.12659/AJCR.931418

Am J Case Rep 2021; 22:e931418

Table 1. Patient laboratory values.

TestDateNormal range
On admissionAfter 1 WeekAfter 4 WeeksAfter 6 WeeksAfter 3 Months
  ALT107.8↑158↑83↑49↑11.310–45 U/L
  AST202.7↑152↑87↑58↑2610–45 U/L
  ALP1200↑1543↑1138↑329↑280↑40–100 U/L
  GGT1350↑716↑130↑60↑11–49.4 U/L
  CPK42003230290067060–400 U/L
  BILD252.5↑276.3↑319.5↑360↑37.3↑≤54 µmol/L
  BILT318.2↑332.5↑393.1↑177↑39.4↑0–21 µmol/L
  TP62.9↓61↓62↓62↓63.2↑65–81 g/L
  Na124.4↓133↓132 I141130↓135–155 mmol/L
  ALB19.05↓10↓13↓23↓21.8↓28–46 g/L
  CREA25↓192↑235↑411↑170↑53–115 µmol/L
  K3.944.24.33.1↓4.33.6–5.5 mmol/L
  Glucose14.2↑9.75↑13.02↑14.4↑12.3↑4.1–5.9 µ mol/L
  Ionized calcium4.–5.6 mg/dL
  Vitamin D262020–0 ng/mL
  INR1.↑1.2↑0.9–1.1 s
  PT14.5514.516.6↑14.6↑12.3–14.2 s
  PTT37.7s40.637.7↑43.8↑40.2↑31.4–38.2 s
ALT – alanine aminotransferase; AST – aspartate transferase; ALP – alkaline phosphatase; GGT – Gamma-glutamyl transpeptidase; CPK – creatine phosphokinase; BILD – bilirubin, direct; BILT – bilirubin, total; TP – protein, total; Na – sodium; ALB – albumin; CREA – creatinine; K – potassium; INR – international normalized ratio; PT – prothrombin time; PTT – partial thromboplastin time.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923