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02 August 2021: Articles

Acquired Thrombotic Thrombocytopenic Purpura Without Anti-ADAMTS13 Antibody Caused by Influenza A (H1N1) Virus Successfully Treated by Plasma Exchange: A Case Report

Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)

Keisuke Kubo A* , Tomohiro Abe A , Noriaki Kawano B , Hidenobu Ochiai A

DOI: 10.12659/AJCR.932251

Am J Case Rep 2021; 22:e932251

Table 2. Laboratory findings at the diagnosis of TMA.

Normal range
Haptoglobin (mg/L)300–2000
ADAMTS13 activity (%)×FRETS-VWF73 assay65.4>70
ADAMTS13 activity (%)× chromogenic act-ELISA assay>70
ADAMTS13 inhibitor (BU)
Anti-LPS-IgM antibodyNegativeNegative
Anti-HIT antibody (U/mL)
Anti-nuclear antibodyNegativeNegative
Anti-CL β2GP antibody (U/mL)
Anti-ds-DNA antibody (IU/mL)
Anti-RNP antibody (U)
Anti-scl-70 antibody (U)
Anti-SS-A antibody (U)
Anti-SS-B antibody(U)
C3 (g/L)1.0875–175
C4 (g/L)0.3814–40
CH50 (U/mL)>60.030–75
ADAMTS13 – a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13; ELISA – enzyme-linked immunosorbent assay; LPS – lipopolysaccharide; IgM – immunoglobulin M; HIT – heparin-induced thrombocytopenia; CL – cardiolipin; IgG – immunoglobulin G; Anti-CL β2GP – anti-cardiolipin antibody/β2-glycoprotein; ss – single-stranded; ds – double-stranded; RNP – ribonucleoprotein; scl-70 – topoisomerase-1; anti-SS-A – anti-Ro; anti-SS-B – anti-La; PR3-ANCA – anti-proteinase 3-antineutrophil cytoplasmic autoantibodies; MPO-ANCA – myeloperoxidase- antineutrophil cytoplasmic autoantibodies; C3 – complement 3; C4 – complement 4; CH50 – 50% hemolytic complement.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923