07 October 2021: Articles
-chiro-inositol Induces Ovulation in Non-Polycystic Ovary Syndrome (PCOS), Non-Insulin-Resistant Young Women, Likely by Modulating Aromatase Expression: A Report of 2 Cases
Unknown etiology, Unusual clinical course, Unusual setting of medical care
Maria Salomé Bezerra Espinola A* , Antonio Simone Laganà E , Gabriele Bilotta F , Giuseppe Gullo C , Cesare Aragona D , Vittorio Unfer DDOI: 10.12659/AJCR.932722
Am J Case Rep 2021; 22:e932722
Table 1. Characteristics of the patients.
| Case 1 | Case 2 | |
|---|---|---|
| Age | 19 | 23 |
| Age at menarche | 11 | 14 |
| No. of cycles/year | 8 | 7 |
| BMI (kg/m) | 24 | 20.1 |
| Fasting glucose (mg/dl) | 76 | 82 |
| OGTT glucose, 120 min (mg/dl) | 56 | 78 |
| Fasting insulin (mIU/L) | 5 | 3.7 |
| OGTT insulin, 120 min (mIU/L) | 16 | 4.9 |
| HOMA-IR index | 0.94 | 0.75 |
| Basal LH (mIU/ml) | 4.3 | 5.7 |
| Basal FSH (mIU/ml) | 7.2 | 6.9 |
| Basal PRL (ng/ml) | 23.5 | 13.6 |
| Basal AMH (ng/ml) | 3.5 | 4.6 |
| Basal testosterone (ng/ml) | 0.2 | 0.5 |
| Basal free testosterone (pg/ml) | 3 | 4 |
| Basal DHT (pg/ml) | 0.2 | 0.3 |
| Basal SHBG (nmol/L) | 40.3 | 56.4 |
| Basal 4-A (ng/ml) | 1.1 | 0.75 |
| Basal DHEAS (mcg/ml) | 1.8 | 3.2 |
| Basal estradiol (pg/ml) | 39.5 | 42 |
| Basal progesterone (ng/ml) | 0.4 | 0.5 |
| Basal endometrium thickness (mm) | 3.4 | 4.5 |
| Dominant pre ovulatory follicle (mm) at day 30 | 20.6 | 22.3 |
| LH at day 30 (mIU/ml) | 13 | 18 |
| Estradiol at day 30 (pg/ml) | 386 | 380 |
| Progesterone at day 30 (ng/ml) | 0.42 | 0.63 |
| Testosterone at day 30 (ng/ml) | 0.32 | 0.48 |
| Endometrium thickness around ovulation at day 30 (mm) | 12 | 13 |
| Estradiol at day 40 (pg/ml) | 172 | 112 |
| Progesterone at day 40 (ng/ml) | 10.3 | 12 |
| BMI – body mass index; OGTT – oral glucose tolerance test; HOMA-IR – homeostatic model assessment for insulin resistance; LH – luteinizing hormone; PRL – prolactin; DHT – dihydrotestosterone; SHBG – sex hormone binding globulin; 4-A – androstenedione; DHEAS – dehydroepiandrosterone sulfate. | ||