D-chiro-inositol Induces Ovulation in Non-Polycystic Ovary Syndrome (PCOS), Non-Insulin-Resistant Young Women, Likely by Modulating Aromatase Expression: A Report of 2 Cases

07 October 2021 : Case report Italy

Unknown etiology, Unusual clinical course, Unusual setting of medical care

Maria Salomé Bezerra Espinola^123A*, Antonio Simone Laganà

^34E, Gabriele Bilotta^5F, Giuseppe Gullo^6C, Cesare Aragona^13DE, Vittorio Unfer^13DE

DOI: 10.12659/AJCR.932722

Am J Case Rep 2021; 22:e932722

Background Case Reports Discussion Conclusions References:

Related articles Order reprints Share article Share by email

View HTML version

Table 1. Characteristics of the patients.

	Case 1	Case 2
Age	19	23
Age at menarche	11	14
No. of cycles/year	8	7
BMI (kg/m)	24	20.1
Fasting glucose (mg/dl)	76	82
OGTT glucose, 120 min (mg/dl)	56	78
Fasting insulin (mIU/L)	5	3.7
OGTT insulin, 120 min (mIU/L)	16	4.9
HOMA-IR index	0.94	0.75
Basal LH (mIU/ml)	4.3	5.7
Basal FSH (mIU/ml)	7.2	6.9
Basal PRL (ng/ml)	23.5	13.6
Basal AMH (ng/ml)	3.5	4.6
Basal testosterone (ng/ml)	0.2	0.5
Basal free testosterone (pg/ml)	3	4
Basal DHT (pg/ml)	0.2	0.3
Basal SHBG (nmol/L)	40.3	56.4
Basal 4-A (ng/ml)	1.1	0.75
Basal DHEAS (mcg/ml)	1.8	3.2
Basal estradiol (pg/ml)	39.5	42
Basal progesterone (ng/ml)	0.4	0.5
Basal endometrium thickness (mm)	3.4	4.5
Dominant pre ovulatory follicle (mm) at day 30	20.6	22.3
LH at day 30 (mIU/ml)	13	18
Estradiol at day 30 (pg/ml)	386	380
Progesterone at day 30 (ng/ml)	0.42	0.63
Testosterone at day 30 (ng/ml)	0.32	0.48
Endometrium thickness around ovulation at day 30 (mm)	12	13
Estradiol at day 40 (pg/ml)	172	112
Progesterone at day 40 (ng/ml)	10.3	12
BMI – body mass index; OGTT – oral glucose tolerance test; HOMA-IR – homeostatic model assessment for insulin resistance; LH – luteinizing hormone; PRL – prolactin; DHT – dihydrotestosterone; SHBG – sex hormone binding globulin; 4-A – androstenedione; DHEAS – dehydroepiandrosterone sulfate.

Back to the Article