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17 August 2021: Articles

Drug-Associated Eosinophilic Fasciitis: A Case of Eosinophilic Fasciitis Secondary to Cemiplimab Therapy

Challenging differential diagnosis, Unusual or unexpected effect of treatment, Unexpected drug reaction, Rare disease, Clinical situation which can not be reproduced for ethical reasons

Sri Harsha Boppana A* , Nageswara Rao Dulla E , Bryce D. Beutler E , Nageshwara Gullapalli A , Ratinder Kaur D

DOI: 10.12659/AJCR.932888

Am J Case Rep 2021; 22:e932888

Table 1. Characteristics of patients with checkpoint inhibitor-induced eosinophilic fasciitis.

Sex/age*Type of malignancyType of CPIMonths until the onset of symptomsIncreased eosinophil countsCPK elevationIndicative biopsyCPI discontinuationSpecific treatmentMalignancy outcomeReference
F/43MelanomaNivolumab14NoNoYesNot reportedGCs, IVIgCRParker []20
M/48Lung adeno- carcinomaAtezolizumab6YesYesYesYesGCs, MTXDPChan []21
F/48Triple-negative breast cancer (TNBC)Atezolizumab7.5YesNoYesYesNoPRWissam []22
F/51MelanomaPembrolizumab18YesNoYesDiscontinued 1 month before the onset of symptomsGCsCRKhoja []23
F/53MelanomaPembrolizumab8Not reportedNot reportedYesYesGCs, MTXCRLidar []24
M/55MelanomaNivolumab24YesNoYesYesGCs, MTXCRRischin []25
F/56Lung adeno- carcinomaNivolumab9YesNoYesYesGCs, MTXSDLe Tallec []26
M/64MelanomaNivolumab11YesNoYesYesGCs, MTX, IVIgResponseOllier []27
M/65Bladder cancerIpilimumab plus nivolumab initially, followed by nivolumab monotherapy16YesNot reportedYesYesGCs, MTXDPLencina []28
M/70MelanomaPembrolizumab8YesNot reportedNoYesGCs, MTXPRChan []21
F/71MelanomaNivolumab3YesNoYesYesGCs, MTXCRChan []21
F/77MelanomaIPILIMUMAB (early withdrawal due to colitis), followed by pembrolizumab monotherapy22YesYesNoYesGCs, MTXCRToussaint []29
F/72Squamous cell carcinomaCemiplimab12NoNot reportedYesYesGCs, sulfasala-zine, hydroxychlo-roquineCRCurrent report
* Age is that at the time of CPI initiation. CPI – checkpoint inhibitor; CR – complete response; PR– partial response; DP – disease progression; SD – stable disease; GCs – glycocorticosteroids; MTX – methotrexate; IVIg – intravenous immunoglobulin.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923