Giant Cell Carcinoma of the Endometrium: A Case Report of a Rare Entity with Aggressive Behavior

09 September 2021: Articles

Challenging differential diagnosis, Rare disease

Maria Arafah ^A* , Raghad Adnan Bokhari ^A , Khalid Akkour ^B , Emadeddin Raddaoui ^A

DOI: 10.12659/AJCR.932916

Am J Case Rep 2021; 22:e932916

Table 1. Reported cases of giant cell carcinoma of the endometrium.

Case	Author, year	Age (years)	Presentation	% of giant cell component	Percentage of conventional cell type	FIGO stage	Reference
1	Jones et al, 1991	43	Vaginal bleeding	15%	Endometrioid (85%)	IA	[]⁴
2	Jones et al, 1991	66	Vaginal bleeding	Predominant	Endometrioid	IA	[]⁴
3	Jones et al, 1991	64	Vaginal bleeding	Predominant	Endometrioid	IA	[]⁴
4	Jones et al, 1991	85	Vaginal bleeding	Predominant	Endometrioid	IIA	[]⁴
5	Jones et al, 1991	63	Vaginal bleeding	15%	Endometrioid (85%)	IVB	[]⁴
6	Jones et al, 1991	71	Vaginal bleeding	Predominant	Endometrioid	IVB	[]⁴
7	Mardi et al, 2008	70	Vaginal bleeding	Predominant	Endometrioid	IIIA	[]⁵
8	Mulligan et al, 2010	53	Vaginal bleeding	70%	Clear cell	IA	[]⁶
9	Mulligan et al, 2010	60	Anemia	100%	Not present	IB	[]⁶
10	Mulligan et al, 2010	58	Vaginal bleeding	50%	Endometrioid with spindle cells	IA	[]⁶
11	Mulligan et al, 2010	83	Pelvic mass	30%	Endometrioid	IIIC2	[]⁶
12	Mulligan et al, 2010	67	Vaginal bleeding	90%	Serous	IA	[]⁶
13	Bhattacharyya et al, 2012	70	Vaginal bleeding	80%	Endometrioid	IB	[]⁷
14	Sharma et al, 2016	60	Vaginal bleeding	60%	Endometrioid	IB	[]⁸
15	Ayık Aydın et al, 2019	75	Vaginal bleeding	Not available	Not available	IIIC	[]⁹
16	Current case	71	Vaginal bleeding	>95%	Not present	IA	Current case