11 January 2022
: Case report 
A Well-Differentiated Grade-3 Neuroendocrine Tumor in the Ascending Colon: A Case Report
Challenging differential diagnosis, Rare coexistence of disease or pathology
Ali AlSaffar1DF, Sarah Wood1BE, Fatma AlRabiy2BCDEF, Dany Hamie3CD, Salah Termos1EF*DOI: 10.12659/AJCR.933792
Am J Case Rep 2022; 23:e933792
Table 1. Comparison between WD-NET G-3 and NEC [15,16].
| Features | NET, G3 | NEC |
|---|---|---|
| Differentiation | Well-differentiated | Poorly-differentiated |
| Pattern of arrangement | Organoid, nests, trabecular, insular | Diffuse sheets of either small or large cells |
| Nuclei | Round, oval with “salt & pepper” chromatin, inconspicuous nucleoli | Atypical, pleomorphic |
| Cytoplasm | Eosinophilic | Basophilic |
| Apoptosis | –/+ | ++ |
| Necrosis | –/+ | +++ |
| Ki-67 index | >20% (up to 50%) | >20% (usually more than 70%) |
| Neuroendocrine markers (chromogranin, synaptophysin) | ++ | + weak |