08 December 2021
: Case report 
Stinging Nettle (Urtica dioica): An Unusual Case of Galactorrhea
Unusual or unexpected effect of treatment, Adverse events of drug therapy
Laura Easton12DEF, Shalini Vaid34ACDEF, Angela K. Nagel5BDEF, Jineane V. Venci6DEF, Robert J. Fortuna126ABDEF*DOI: 10.12659/AJCR.933999
Am J Case Rep 2021; 22:e933999
Table 1. Proposed mechanisms of Urtica dioica-induced galactorrhea.
| Potential mechanism | Description |
|---|---|
| Inhibition of Sex-hormone binding globulin (SHBG) | Inhibition of SHBG may result in increased levels of unbound estrogen which produce hormonal actions, including galactorrhea []2 |
| Histamine mediated | Histamine contained in the hairs of leaves of may stimulate prolactin release [–]8 |
| Serotonin mediated | Serotonin has been isolated in . Serotoninergic inhibition of dopamine may stimulate prolactin release. Additionally, serotonin may stimulate thyrotropin-releasing hormone (TRH) which in turn stimulates prolactin release [,–]9 |